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Comment
. 2017 Dec;14(12):951-953.
doi: 10.1038/cmi.2017.62. Epub 2017 Aug 7.

New therapeutic perspectives in Type 1 Diabetes: dietary interventions prevent β cell-autoimmunity by modifying the gut metabolic environment

Chiara Sorini  1 , Ilaria Cosorich  2 , Marika Falcone  2
Affiliations
Comment

New therapeutic perspectives in Type 1 Diabetes: dietary interventions prevent β cell-autoimmunity by modifying the gut metabolic environment

Chiara Sorini et al. Cell Mol Immunol. 2017 Dec.
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A SCFA-enriched gut metabolic environment prevents autoimmune diabetes. Specialized diets that trigger release of high amounts of acetate or butyrate upon bacterial fermentation prevent autoimmune diabetes. Acetate predominantly act on B cells by reducing their antigen-presenting function and capacity to spread autoimmune T cell responses to various self epitopes of islet antigens. Butyrate expands the FoxP3+ Treg cell subset that is crucial to maintain self tolerance and prevents autoimmune diabetes. Both immunomodulatory effects are mediated by epigenetic mechanisms that involve histone modifications: increase of histone-deacetylase (HDAC) activity in B cells and FoxP3 locus acetylation in FoxP3+ Treg cells.
Figure 2
Figure 2
Diet and other environmental factors modulate autoimmune diabetes by modifying the gut metabolic environment. Specific dietary components such as soluble fibers and omega-3 fat but also antibiotics and hygenic conditions have a strong impact on the microbiota composition. Those factors modulate the relative abundance of SCFA-producing microbial species and have a strong impact on the gut metabolic environment thus affecting the immune regulatory mechanisms that are controlled at the intestinal level.
See this image and copyright information in PMC

Comment on

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