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Review
. 2017 Aug 7;5(3):21.
doi: 10.3390/proteomes5030021.

Role of Salivary Biomarkers in Detection of Cardiovascular Diseases (CVD)

Saad Abdul Rehman  1 , Zohaib Khurshid  2 , Fayez Hussain Niazi  3 , Mustafa Naseem  4 , Hamed Al Waddani  5 , Haafsa Arshad Sahibzada  6 , Rabia Sannam Khan  7
Affiliations
Review

Role of Salivary Biomarkers in Detection of Cardiovascular Diseases (CVD)

Saad Abdul Rehman et al. Proteomes. .

Abstract

Human whole mouth saliva (WMS) is secreted by salivary glands, namely parotid, submandibular/sublingual and other minor glands of the oral cavity. It is secreted in a systematic way, and contain informative proteins and peptides for the early detection of contagious diseases and organ-related diseases. The role of WMS as a liquid biopsy for the detection of cardiovascular diseases (CVD) through Myoglobin (MYO), Cardiac troponin I (cTnI), Creatine phosphokinase MB (CK-MB), Myeloperoxidase (MPO), brain natriuretic peptide (NT-proBNP), Exosomal miRNA, C-Reactive Protein (CRP), Matrix metalloproteinase-8 (MMP-8), MMP-9 and tissue inhibitor of MMP-8 (TIMP-1), leukotriene B4 has been well reported in last decade, that have been reviewed in the literature comprehensively below.

Keywords: biomarkers; cardiovascular diseases and diagnosis; proteins; saliva.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Illustration of a drop of whole mouth saliva representing its detailed composition.
Figure 2
Figure 2
Illustration is representing the sources of human salivary biomarkers.
See this image and copyright information in PMC

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