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. 1986 Jan;6(1):337-41.
doi: 10.1128/mcb.6.1.337-341.1986.

Regulation of insulin mRNA abundance and adenylation: dependence on hormones and matrix substrata

R Muschel, G Khoury, L M Reid

Regulation of insulin mRNA abundance and adenylation: dependence on hormones and matrix substrata

R Muschel et al. Mol Cell Biol. 1986 Jan.

Abstract

The insulin mRNA levels of rat insulinoma cell lines increased six- to eightfold, and the cells entered a transient state of growth arrest when they were cultured in serum-free, hormonally defined medium and on an extract of extracellular matrix derived from a basement membrane-secreting tumor line, EHS. Insulinoma cultures in growth arrest responded to glucose with a two- to threefold increase in insulin secretion associated with an insulin mRNA that contained a poly(A) tail that was 120 to 140 bases longer than normal.

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