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. 2017 Aug 31;15(3):222-228.
doi: 10.9758/cpn.2017.15.3.222.

The Relationship between the SNAP-25 Polymorphism and Omission Errors in Korean Children with Attention Deficit Hyperactivity Disorder

Eunjoo Kim  1 , Dong-Ho Song  2 , Nam-Wook Kim  2 , In-Jung Sohn  2 , Keun-Ah Cheon  2
Affiliations

The Relationship between the SNAP-25 Polymorphism and Omission Errors in Korean Children with Attention Deficit Hyperactivity Disorder

Eunjoo Kim et al. Clin Psychopharmacol Neurosci. .

Abstract

Objective: This study aimed to investigate the association between the synaptosomal-associated protein 25 kDa (SNAP-25) genotype and performance on the continuous performance test (CPT) in Korean children with attention-deficit/hyperactivity disorder (ADHD).

Methods: Eighty-seven children with ADHD (mean age, 9.23±1.99 years) participated in this study. Omission errors, commission errors, reaction time, and reaction time variability on the CPT were analyzed. The single-nucleotide polymorphism (SNP) rs3746544 (1065 T＞G) of SNAP-25 was genotyped to examine the association with CPT performance.

Results: We found significantly more omission errors on the CPT among children with the TT genotype of SNAP-25 (t=2.56, p=0.012) after correcting for multiple testing.

Conclusion: Our results suggest the possible involvement of the SNAP-25 1065 T＞G polymorphism in the inattention phenotype in children with ADHD. Further studies with more refined neuropsychological measures and much larger sample sizes are needed to confirm our findings.

Keywords: Attention deficit disorder with hyperactivity; Continuous performance test; Omission errors; SNAP-25.

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References

    1. Biederman J, Faraone SV. Attention-deficit hyperactivity disorder. Lancet. 2005;366:237–248. doi: 10.1016/S0140-6736(05)66915-2. - DOI - PubMed
    1. Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, et al. Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;57:1313–1323. doi: 10.1016/j.biopsych.2004.11.024. - DOI - PubMed
    1. Heiser P, Friedel S, Dempfle A, Konrad K, Smidt J, Grabarkiewicz J, et al. Molecular genetic aspects of attention-deficit/hyperactivity disorder. Neurosci Biobehav Rev. 2004;28:625–641. doi: 10.1016/j.neubiorev.2004.09.010. - DOI - PubMed
    1. Doyle AE, Faraone SV, Seidman LJ, Willcutt EG, Nigg JT, Waldman ID, et al. Are endophenotypes based on measures of executive functions useful for molecular genetic studies of ADHD? J Child Psychol Psychiatry. 2005;46:774–803. doi: 10.1111/j.1469-7610.2005.01476.x. - DOI - PubMed
    1. Doyle AE, Willcutt EG, Seidman LJ, Biederman J, Chouinard VA, Silva J, et al. Attention-deficit/hyperactivity disorder endophenotypes. Biol Psychiatry. 2005;57:1324–1335. doi: 10.1016/j.biopsych.2005.03.015. - DOI - PubMed