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. 2017 Jul 21;23(27):4968-4977.
doi: 10.3748/wjg.v23.i27.4968.

New formula for predicting standard liver volume in Chinese adults

Ling-Mei Feng  1 , Pei-Qin Wang  1 , Hong Yu  1 , Ru-Tan Chen  1 , Jian Wang  1 , Xia Sheng  1 , Zong-Li Yuan  1 , Pei-Mei Shi  1 , Wei-Fen Xie  1 , Xin Zeng  1
Affiliations

New formula for predicting standard liver volume in Chinese adults

Ling-Mei Feng et al. World J Gastroenterol. .

Abstract

Aim: To obtain a reference range of morphological indices and establish a formula to accurately predict standard liver volume (SLV) in Chinese adults.

Methods: Computed tomography (CT)-estimated total liver volume (CTLV) was determined in 369 Chinese adults. Age, sex, body weight, body height, body mass index, and body surface area (BSA) were recorded using CT. Total splenic volume, portal venous diameter (PVD), splenic venous diameter (SVD), and portal venous cross-sectional area (PVCSA) were also measured by CT. Stepwise multiple linear regression analysis was performed to evaluate the impact of each parameter on CTLV and to develop a new SLV formula. The accuracy of the new formula was compared with the existing formulas in a validation group.

Results: The average CTLV was 1205.41 ± 257.53 cm3 (range, 593.80-2250.10 cm3). The average of PVD, SVD and PVCSA was 9.34 ± 1.51 mm, 7.40 ± 1.31 mm and 173.22 ± 48.11 mm2, respectively. The CT-estimated splenic volume of healthy adults varied markedly (range, 46.60-2892.30 cm3). Sex, age, body height, body weight, body mass index, and BSA were significantly correlated with CTLV. BSA showed the strongest correlation (r = 0.546, P < 0.001), and was used to establish a new model for calculating SLV: SLV (cm3) = 758.259 × BSA (m2)-124.272 (R2 = 0.299, P < 0.001). This formula also predicted CTLV more accurately than the existing formulas, but overestimated CTLV in elderly subjects > 70 years of age, and underestimated liver volume when CTLV was > 1800 cm3.

Conclusion: Our new BSA-based formula is more accurate than other formulas in estimating SLV in Chinese adults.

Keywords: Chinese adults; Morphological indices; Reference range; Standard liver volume.

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Conflict of interest statement

Conflict-of-interest statement: The authors of this manuscript have no conflicts of interest to disclose.

Figures

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Figure 1
Figure 1
Correlation between computed tomography estimated total liver volume and body surface area of 244 healthy adults. The 95%CI is shown (Dotted line). BSA: Body surface area; CTLV: Computed tomography estimated total liver volume.
Figure 2
Figure 2
Correlation between standard liver volume calculated by the new formula and Urata’s formula. SLV: Standard liver volume.
Figure 3
Figure 3
Correlation between standard liver volume calculated by the new formula and computed tomography estimated total liver volume stratified according to age. CTLV: Computed tomography estimated total liver volume; SLV: Standard liver volume.
Figure 4
Figure 4
Modified Bland-Altman plots of the volume differences and computed tomography estimated total liver volume. CTLV: Computed tomography estimated total liver volume; SLV: Standard liver volume.
See this image and copyright information in PMC

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