Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jul 21:8:175.
doi: 10.3389/fendo.2017.00175. eCollection 2017.

Thyroid Autoimmunity and Antiphospholipid Syndrome: Not Such a Trivial Association

Mathilde Versini  1
Affiliations
Review

Thyroid Autoimmunity and Antiphospholipid Syndrome: Not Such a Trivial Association

Mathilde Versini. Front Endocrinol (Lausanne). .

Abstract

Antiphospholipid syndrome (APS) is an autoimmune disease that manifests as recurrent venous or arterial thrombosis and/or pregnancy-related complications in the presence of persistent antiphospholipid (aPL) antibodies measured at least 3 months apart. APS occurs either as a primary condition or as a part of an underlying disorder, usually systemic lupus erythematosus (SLE). Otherwise, APS may be frequently associated with autoimmune disorders. Little is known about the association of APS and aPL antibodies with thyroid autoimmune diseases or thyroid autoantibodies. This is even more interesting that thyroid autoantibodies and aPL are both recognized causes of repeated miscarriages. Therefore, their combination is of particular importance in women of childbearing age. Several studies have pointed out an association between APS and thyroid autoimmunity, some of them suggesting common pathophysiologic processes and genetic background. A literature review was conducted on existing data on aPL/APS and thyroid autoimmune disorders, paying particular attention to the possible role of this association in obstetrical complications.

Keywords: Graves’ disease; Hashimoto’s thyroiditis; antiphospholipid syndrome; autoimmune disease; autoimmunity; thyroid.

PubMed Disclaimer

References

    1. Antonelli A, Ferrari SM, Corrado A, Di Domenicantonio A, Fallahi P. Autoimmune thyroid disorders. Autoimmun Rev (2015) 14(2):174–80.10.1016/j.autrev.2014.10.016 - DOI - PubMed
    1. McLeod DSA, Cooper DS. The incidence and prevalence of thyroid autoimmunity. Endocrine (2012) 42(2):252–65.10.1007/s12020-012-9703-2 - DOI - PubMed
    1. Golden SH, Robinson KA, Saldanha I, Anton B, Ladenson PW. Clinical review: prevalence and incidence of endocrine and metabolic disorders in the United States: a comprehensive review. J Clin Endocrinol Metab (2009) 94(6):1853–78.10.1210/jc.2008-2291 - DOI - PMC - PubMed
    1. Vanderpump MPJ. The epidemiology of thyroid disease. Br Med Bull (2011) 99:39–51.10.1093/bmb/ldr030 - DOI - PubMed
    1. Caturegli P, De Remigis A, Rose NR. Hashimoto thyroiditis: clinical and diagnostic criteria. Autoimmun Rev (2014) 13(4–5):391–7.10.1016/j.autrev.2014.01.007 - DOI - PubMed

LinkOut - more resources