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. 2017 Jul 14;5(3):2324709617721251.
doi: 10.1177/2324709617721251. eCollection 2017 Jul-Sep.

Adenocarcinoma of Lung Presenting as Lambert-Eaton Myasthenic Syndrome

Sumera Bukhari  1 , Rabia Soomro  1 , Shaikh Fawwad  1 , Chikezie Alvarez  1 , Sara Wallach  1
Affiliations

Adenocarcinoma of Lung Presenting as Lambert-Eaton Myasthenic Syndrome

Sumera Bukhari et al. J Investig Med High Impact Case Rep. .

Abstract

Lambert-Eaton myasthenic syndrome (LEMS) is a paraneoplastic neuromuscular junction disorder. LEMS presents with muscular weakness and fatigability, mainly involving the proximal lower limbs. There are 2 types of LEMS depending on the etiology: paraneoplastic and idiopathic. The paraneoplastic form, which constitutes more than a half of the cases, is mostly associated with intrathoracic neoplasms. Most cases are seen in patients with small cell lung cancer; other subtypes of lung cancer are extremely rare. In this article, we report a case of LEMS as a rare association with adenocarcinoma of the lung.

Keywords: Lambert-Eaton myasthenic syndrome; adenocarcinoma of lung; lung cancer; neuromuscular disorder; paraneoplastic syndrome.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure-1.
Figure-1.
Chest X-ray showing a 4.3 cm right upper lobe lung mass.
Figure-2.
Figure-2.
Computed tomography scan of the chest showing a right upper lobe lung mass.
See this image and copyright information in PMC

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References

    1. Ramos-Yeo YL, Reyes CV. Myasthenic syndrome (Eaton-Lambert syndrome) associated with pulmonary adenocarcinoma. J Surg Oncol. 1987;34:239-242. - PubMed
    1. Sumitomo M, Uyama T, Kimura S, Hashioka K, Nobuhara K, Monden Y. A case of Lambert-Eaton myasthenic syndrome associated with adenocarcinoma of the lung. Haigan. 1989;29:167-172.
    1. Okudera K, Ebina A, Imai S, et al. A case with adenocarcinoma of the lung accompanied Lambert-Eaton myasthenic syndrome. Nikkyo. 1996;55:902-907.
    1. Milanez FM, Pereira CA, Trindade PH, Milinavicius R, Coletta EN. Lung adenocarcinoma, dermatomyositis, and Lambert-Eaton myasthenic syndrome: a rare combination. J Bras Pneumol. 2008;34:333-336. - PubMed
    1. Arai H, Inui K, Hashimoto K, et al. Lung adenocarcinoma with Lambert-Eaton myasthenic syndrome indicated by voltage-gated calcium channel: a case report. J Med Case Rep. 2012;6:281. - PMC - PubMed

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