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. 2015 Jan 29:7:1-5.
doi: 10.1016/j.ijcha.2015.01.012. eCollection 2015 Jun 1.

Cardiac calcified amorphous tumor: A systematic review of the literature

Quentin de Hemptinne  1 , Didier de Cannière  2 , Jean-Luc Vandenbossche  1 , Philippe Unger  1
Affiliations

Cardiac calcified amorphous tumor: A systematic review of the literature

Quentin de Hemptinne et al. Int J Cardiol Heart Vasc. .

Abstract

Background: Calcified amorphous tumor (CAT) of the heart is a rare non-neoplastic intracavitary cardiac mass. Several case reports have been published but large series are lacking.

Objective: To determine clinical features, current management and outcomes of this rare disease.

Design: A systematic review of all articles reporting cases of CAT in order to perform a pooled analysis of its clinical features, management and outcomes.

Data sources: An electronic search of all English articles using PUBMED was performed. Further studies were identified by cross-referencing from relevant papers.

Inclusion criteria: We restricted inclusion to articles reporting cases of CAT in the English language literature published up to July 2014.

Data extraction: One author performed data extraction using predefined data fields.

Results: A total of 27 articles, reporting 42 cases of CAT were found and included in this review.

Conclusion: In this review, the most frequent presenting symptoms were dyspnea and embolic events. Mitral valve and annulus were the most frequent location of CAT. Surgery was most of the time required to confirm diagnosis, and was relatively safe. Overall outcome after surgical resection was good.

Keywords: Calcified amorphous tumor; Heart; Mass; Nonneoplastic; Review.

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Figures

Fig. 1
Fig. 1
2D echocardiography of CAT (personal unpublished data). Echocardiographic four chamber view (Panel A) showing a mobile mass of 7 × 9 mm, attached on the ventricular side of the mitral annulus, close to the posterior commissure. Zoom view (Panel B) allows characterizing the relationship of the mass (small arrows) with the mitral leaflets (large arrows). LV, left ventricle; LA, left atrium.
Fig. 2
Fig. 2
CAT microscopic image (personal unpublished data). Microscopic findings showing heterogeneous calcium deposits with surrounding amorphous eosinophilic and fibrinous material (hematoxilin and eosin, original × 100).
See this image and copyright information in PMC

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