Application of the qSOFA score to predict mortality in patients with suspected infection in a resource-limited setting in Malawi

Michaëla A M Huson^{1

2

3}, Chawezi Katete⁴, Lilian Chunda⁴, Jonathan Ngoma⁴, Claudia Wallrauch⁴, Tom Heller^{4

5}, Tom van der Poll⁶, Martin P Grobusch^{6

7}

Affiliations

¹ Division of Infectious Diseases, Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-105, 1105 AZ, Amsterdam, The Netherlands. m.a.huson@amc.uva.nl.
² Division of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. m.a.huson@amc.uva.nl.
³ Medical Department, Kamuzu Central Hospital, Lilongwe, Malawi. m.a.huson@amc.uva.nl.
⁴ Medical Department, Kamuzu Central Hospital, Lilongwe, Malawi.
⁵ Lighthouse HIV Clinic, Kamuzu Central Hospital, Lilongwe, Malawi.
⁶ Division of Infectious Diseases, Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-105, 1105 AZ, Amsterdam, The Netherlands.
⁷ Division of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

PMID: 28786004
PMCID: PMC5696439
DOI: 10.1007/s15010-017-1057-5

Application of the qSOFA score to predict mortality in patients with suspected infection in a resource-limited setting in Malawi

Michaëla A M Huson et al. Infection. 2017 Dec.

. 2017 Dec;45(6):893-896.

doi: 10.1007/s15010-017-1057-5. Epub 2017 Aug 7.

Authors

Michaëla A M Huson^{1

2

3}, Chawezi Katete⁴, Lilian Chunda⁴, Jonathan Ngoma⁴, Claudia Wallrauch⁴, Tom Heller^{4

5}, Tom van der Poll⁶, Martin P Grobusch^{6

7}

Affiliations

¹ Division of Infectious Diseases, Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-105, 1105 AZ, Amsterdam, The Netherlands. m.a.huson@amc.uva.nl.
² Division of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. m.a.huson@amc.uva.nl.
³ Medical Department, Kamuzu Central Hospital, Lilongwe, Malawi. m.a.huson@amc.uva.nl.
⁴ Medical Department, Kamuzu Central Hospital, Lilongwe, Malawi.
⁵ Lighthouse HIV Clinic, Kamuzu Central Hospital, Lilongwe, Malawi.
⁶ Division of Infectious Diseases, Center of Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-105, 1105 AZ, Amsterdam, The Netherlands.
⁷ Division of Infectious Diseases, Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

PMID: 28786004
PMCID: PMC5696439
DOI: 10.1007/s15010-017-1057-5

Abstract

Purpose: To determine the predictive value of qSOFA (quick Sequential Organ Failure Assessment) in Malawian patients with suspected infection.

Methods: Prospective observational study in a tertiary referral hospital in Malawi.

Results: Predictive ability of qSOFA was reasonable [AUROC 0.73 (95% CI 0.68-0.78)], increasing to 0.77 (95% CI 0.72-0.82) when classifying all patients with altered mental status as high risk. Adding HIV status as a variable to the qSOFA score did not improve predictive value.

Conclusion: qSOFA is a simple tool that can aid risk stratification in resource-limited settings.

Keywords: HIV; Resource-limited setting; Sepsis; qSOFA.

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Conflict of interest statement

On behalf of all authors, the corresponding author states that there is no conflict of interest.

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References

1. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3) JAMA. 2016;315:801–810. doi: 10.1001/jama.2016.0287. - DOI - PMC - PubMed
1. Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, et al. Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (sepsis-3) JAMA. 2016;315:762–774. doi: 10.1001/jama.2016.0288. - DOI - PMC - PubMed
1. Huson MA, Kalkman R, Grobusch MP, van der Poll T. Predictive value of the qSOFA score in patients with suspected infection in a resource limited setting in Gabon. Travel Med Infect Dis. 2016;15:76–77. doi: 10.1016/j.tmaid.2016.10.014. - DOI - PubMed
1. Harrington B, Kyriakos Vorkas C, Kanyama C, Ngoma J, Hoffman I, Hosseinipour MC. Altered mental status is an indicator of mortality and associated with both infectious and non-communicable disease in Lilongwe, Malawi. Trop Dr. 2015;45:164–167. - PMC - PubMed
1. Kolditz M, Scherag A, Rohde G, Ewig S, Welte T, Pletz M, et al. Comparison of the qSOFA and CRB-65 for risk prediction in patients with community-acquired pneumonia. Intensive Care Med. 2016;42:2108–2110. doi: 10.1007/s00134-016-4517-y. - DOI - PubMed

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Application of the qSOFA score to predict mortality in patients with suspected infection in a resource-limited setting in Malawi

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Application of the qSOFA score to predict mortality in patients with suspected infection in a resource-limited setting in Malawi

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