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. 2018 Feb;33(1):5-11.
doi: 10.1177/1533317517724000. Epub 2017 Aug 8.

Undetected Peripheral Arterial Disease Among Older Adults With Alzheimer's Disease and Other Dementias

Ilker Tasci  1   2 , Umut Safer  3 , Mehmet Ilkin Naharci  1   2 , Mustafa Gezer  1   2 , Orhan Demir  1   2 , Ergun Bozoglu  1   2 , Huseyin Doruk  1   2
Affiliations

Undetected Peripheral Arterial Disease Among Older Adults With Alzheimer's Disease and Other Dementias

Ilker Tasci et al. Am J Alzheimers Dis Other Demen. 2018 Feb.

Abstract

Background: Peripheral arterial disease (PAD) was reported to increase the risk of dementia(s) even more than stroke. We assessed the prevalence of PAD in a group with definite diagnosis of dementia.

Methods: Patients aged 65 years or older with Alzheimer's disease (AD), vascular dementia (VaD), or AD-VaD were enrolled (n = 162, mean age: 78.87 [6.05] years). An age- and gender-matched control group was also included (n = 190). Peripheral arterial disease was diagnosed by the ankle-brachial index.

Results: Frequency of PAD among patients with and without dementia was 35.2% and 16.3%, respectively ( P < .001), being similar among different types of dementia. After adjustment for covariates, dementia (odds ratio: 2.41, 95% confidence interval: 1.34-4.32; P = .003) was among the predictors of PAD diagnosis along with older age, female gender, and diabetes.

Conclusions: The prevalence of PAD was more than double in patients with dementia, with no difference among AD, VaD, and AD-VaD types.

Keywords: Alzheimer’s disease; ankle–brachial index; dementia; elderly; peripheral arterial disease; vascular dementia.

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Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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