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Review
. 2017 Oct;112(10):1509-1525.
doi: 10.1038/ajg.2017.212. Epub 2017 Aug 8.

Hereditary Colorectal Polyposis and Cancer Syndromes: A Primer on Diagnosis and Management

Priyanka Kanth  1 , Jade Grimmett  2   3 , Marjan Champine  2   3 , Randall Burt  1   2   4 , N Jewel Samadder  1   2   5
Affiliations
Review

Hereditary Colorectal Polyposis and Cancer Syndromes: A Primer on Diagnosis and Management

Priyanka Kanth et al. Am J Gastroenterol. 2017 Oct.

Abstract

Colorectal cancer (CRC) is the fourth most common cancer amongst men and women. Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), and several hamartomatous polyposis conditions. Identification of these patients through family history and appropriate genetic testing can provide estimates of cancer risk that inform appropriate cancer screening, surveillance and/or preventative interventions. This narrative review examines the hereditary colorectal cancer and polyposis syndromes, their genetic basis, clinical management, and evidence supporting cancer screening.

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References

    1. Am J Gastroenterol. 2012 May;107(5):770-8 - PubMed
    1. Cancer Prev Res (Phila). 2008 Nov;1(6):470-5 - PubMed
    1. Ann Surg. 1993 Feb;217(2):101-8 - PubMed
    1. Gastroenterology. 2004 Aug;127(2):444-51 - PubMed
    1. Eur J Hum Genet. 2004 Jan;12(1):52-8 - PubMed

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