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Comment
. 2017 Aug 8;35(8):720-721.
doi: 10.1038/nbt.3934.

Big data opens a window onto wellness

Atul J Butte  1
Affiliations
Comment

Big data opens a window onto wellness

Atul J Butte. Nat Biotechnol. .
No abstract available

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Conflict of interest statement

Conflict of interest statement: The author has a minor investment in Illumina and other biotech companies. He is a cofounder and consultant to Personalis, a company offering services in medical genome sequencing. The author is a scientific advisor to Geisinger Health System, Helix, and uBiome. In the recent past, he has been a consultant to Regeneron, 10x Genomes, Verinata, and Pathway Genomics.

Figures

Figure
Figure
An individual that undergoes multi-modality molecular testing (including germline DNA sequencing) already comes to the test with a wide range of pre-test probability of disease, given what he and she grew up with, including radical changes in smoking rates, environmental exposures, feeding patterns, and much more. Then, when a complex test then indicates a higher rate of a particular disease, what exactly does this mean? Does this mean a disease may appear in the next year, or within the lifetime? Is this a disease that the individual will need to be concerned about? Modeling these details in pre-test and post-test probabilities are crucially needed now, so individuals and their medical professionals can get more specific utility out of testing.
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