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Review
. 2015 Apr 15;8(4):1778-1816.
doi: 10.3390/ma8041778.

Bone Regeneration Using Bone Morphogenetic Proteins and Various Biomaterial Carriers

Zeeshan Sheikh  1 , Mohammad Ahmad Javaid  2 , Nader Hamdan  3 , Raheel Hashmi  4
Affiliations
Review

Bone Regeneration Using Bone Morphogenetic Proteins and Various Biomaterial Carriers

Zeeshan Sheikh et al. Materials (Basel). .

Abstract

Trauma and disease frequently result in fractures or critical sized bone defects and their management at times necessitates bone grafting. The process of bone healing or regeneration involves intricate network of molecules including bone morphogenetic proteins (BMPs). BMPs belong to a larger superfamily of proteins and are very promising and intensively studied for in the enhancement of bone healing. More than 20 types of BMPs have been identified but only a subset of BMPs can induce de novo bone formation. Many research groups have shown that BMPs can induce differentiation of mesenchymal stem cells and stem cells into osteogenic cells which are capable of producing bone. This review introduces BMPs and discusses current advances in preclinical and clinical application of utilizing various biomaterial carriers for local delivery of BMPs to enhance bone regeneration.

Keywords: BMPs; biomaterials; bone morphogenetic proteins; bone regeneration; carrier methods.

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Conflict of interest statement

There are no conflicts of interest for any of the authors who prepared this manuscript.

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