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Randomized Controlled Trial
. 2017 Nov;20(16):2998-3007.
doi: 10.1017/S1368980017001811. Epub 2017 Aug 9.

Effects of lipid-based nutrient supplements v. micronutrient powders on nutritional and developmental outcomes among Peruvian infants

Susana L Matias  1 , Alejandro Vargas-Vásquez  2 , Ricardo Bado Pérez  3 , Lorena Alcázar Valdivia  4 , Oscar Aquino Vivanco  5 , Amelia Rodriguez Martín  6 , Jose Pedro Novalbos Ruiz  6
Affiliations
Randomized Controlled Trial

Effects of lipid-based nutrient supplements v. micronutrient powders on nutritional and developmental outcomes among Peruvian infants

Susana L Matias et al. Public Health Nutr. 2017 Nov.

Abstract

Objective: To determine the effects of lipid-based nutrient supplements (LNS) on children's Hb, linear growth and development, compared with supplementation with micronutrient powder (MNP).

Design: The study was a two-arm parallel-group randomized controlled trial, where participants received either LNS or MNP for daily consumption during 6 months. Supplements were delivered by staff at government-run health centres. Hb, anthropometric, motor development, language development and problem-solving indicators were measured by trained research assistants when children were 12 months of age.

Setting: The study was conducted in five rural districts in the Province of Ambo in the Department of Huánuco, Peru.

Subjects: We enrolled 6-month-old children (n 422) at nineteen health centres.

Results: Children who received LNS had a higher mean Hb concentration and lower odds of anaemia than those who received MNP. No significant differences in height-for-age, weight-for-height or weight-for-age Z-score, or stunting and underweight prevalence, were observed. Provision of LNS was associated with a higher pre-verbal language (gestures) score, but such effect lost significance after adjustment for covariates. Children in the LNS group had higher problem-solving task scores and increased odds of achieving this cognitive task than children in the MNP group. No significant differences were observed on receptive language or gross motor development.

Conclusions: LNS between 6 and 12 months of age increased Hb concentration, reduced anaemia and improved cognitive development in children, but showed no effects on anthropometric indicators, motor or language development.

Keywords: Anaemia; Child development; Lipid-based nutrient supplement; Micronutrient powder; Peru; Problem solving; Stunting.

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Figures

Fig. 1
Fig. 1
Flow diagram of study participation (LNS, lipid-based nutrient supplement; MNP, micronutrient powder)
See this image and copyright information in PMC

References

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