Editorial
doi: 10.1016/j.jsbmb.2017.08.001.
Epub 2017 Aug 5.
New developments in the rapid actions of steroids and their receptors
Affiliations
- PMID: 28789973
- PMCID: PMC6048249
- DOI: 10.1016/j.jsbmb.2017.08.001
Item in Clipboard
Editorial
New developments in the rapid actions of steroids and their receptors
J Steroid Biochem Mol Biol.
2018 Feb.
No abstract available
Conflict of interest statement
COMPETING INTERESTS
E.R.P. is an inventor on U.S. patents 7,875,721 and 8,487,100 for GPER-selective ligands and imaging agents and applications for the therapeutic use of compounds targeting GPER.
Figures
Steroid hormones mediate their effects on cells through multiple receptor types (SR, steroid receptor), including classical nuclear steroid hormone receptors (e.g. ERα), located in the cytoplasm (green), nucleus (red) or tethered to the plasma membrane (yellow), and transmembrane receptors (e.g. GPER), localized either to the plasma membrane (dark purple), intracellular membranes (light purple) or possibly the nucleus (not shown). Steroid receptors can either directly (red arrow) or indirectly (via other transcription factors, purple arrow) regulate gene expression; they also stimulate multiple “rapid” signaling pathways, such as Src, MAPK, PI3K, NOS and Ca++ mobilization, which can also modulate the activity of classical steroid receptors, including independently of steroid binding (blue arrow). The interactions of these multiple receptors and pathways for a single steroid hormone are clearly complex and complicated further by interactions with other steroid and non-steroid receptors and signaling pathways.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
