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. 2017 Jul;60(4):350-356.
doi: 10.5468/ogs.2017.60.4.350. Epub 2017 Jul 14.

Prognostic assessment of sarcomatous histologic subtypes of ovarian carcinosarcoma

Hyun Jin Kim  1 , Hyun-Mi Lee  1 , Mi Kyung Kim  1 , Yoo-Kyung Lee  1 , In-Ho Lee  1 , Ki-Heon Lee  1 , Hyesun Kim  2
Affiliations

Prognostic assessment of sarcomatous histologic subtypes of ovarian carcinosarcoma

Hyun Jin Kim et al. Obstet Gynecol Sci. 2017 Jul.

Abstract

Objective: Ovarian carcinosarcoma is a rare subtype of this disease that has not been thoroughly investigated. The aim of this study was to evaluate the prognostic factors and out comes in patients with ovarian carcinosarcoma.

Methods: All patients with histologically confirmed ovarian carcinosarcoma who were treated at Cheil General Hospital and Women's Healthcare Center between January 2000 and December 2015 were identified and analyzed. Data were extracted from medical records, and statistical analyses were performed to determine correlations between clinicopathological parameters and survival outcomes.

Results: Of the 822 patients diagnosed with ovarian cancer over 16 years, 11 (1.3%) had ovarian carcinosarcoma histology. Every patient underwent surgery as the initial treatment followed by intravenous adjuvant chemotherapy. Only 18.1% of cases were early stage (I or II) while 81.8% were advanced stage (III or IV) according to the FIGO (International Federation of Gynecology and Obstetrics) classification. Six cases were of the homologous subtype (54.5%) and five were of the heterologous subtype (45.5%). There was no significant difference in survival according to stage (P=0.24). The heterologous subtype and residual disease were associated with poor disease-free survival (P=0.02 and P=0.04) and overall survival (P=0.02 and P=0.04), On multivariate analysis, the histological subtype was an independent prognostic factor (P=0.02).

Conclusion: Optimal cytoreduction without gross residual disease and a homologous subtype are favorable prognostic factors in terms of disease relapse and survival.

Keywords: Carcinosarcoma; Histology; Ovarian neoplasms; Prognosis.

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Conflict of interest statement

Conflict of interest: No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. Kaplan-Meier survival curves according to the histopathological subtype. (A) Disease-free survival and (B) overall survival.
Fig. 2
Fig. 2. Kaplan-Meier survival curves according to the presence of a residual mass. (A) Disease-free survival and (B) overall survival.
See this image and copyright information in PMC

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