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. 2017 Aug 7;4(4):ENEURO.0178-17.2017.
doi: 10.1523/ENEURO.0178-17.2017. eCollection 2017 Jul-Aug.

Normal Striatal Vesicular Acetylcholine Transporter Expression in Tourette Syndrome

Roger L Albin  1   2   3 , Christine Minderovic  4 , Robert A Koeppe  3   4
Affiliations

Normal Striatal Vesicular Acetylcholine Transporter Expression in Tourette Syndrome

Roger L Albin et al. eNeuro. .

Abstract

Considerable prior work suggests basal ganglia dysfunction in Tourette syndrome (TS). Analysis of a small number of postmortem specimens suggests deficits of some striatal interneuron populations, including striatal cholinergic interneurons. To assess the integrity of striatal cholinergic interneurons in TS, we used [18F]FEOBV positron emission tomography (PET) to quantify striatal vesicular acetylcholine transporter (VAChT) expression, a measure of cholinergic terminal density, in human TS and control subjects. We found no evidence of striatal cholinergic deficits. Discrepant imaging and postmortem analysis results may reflect agonal or postmortem changes, medication effects, or significant disease heterogeneity.

Keywords: Acetylcholine; Striatum; Tourette Syndrome; VChAT.

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Figures

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Figure 1. Striatal cholinergic terminal density measured by [18F]FEOBV PET in control (top row) and TS (bottom row) subjects. Averaged images from all subjects and images thresholded to optimize visualization of striatal [18F]FEOBV binding. No difference in striatal [18F]FEOBV binding between TS and NC subjects.
See this image and copyright information in PMC

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