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Comparative Study
. 2017 Sep-Oct;43(5):849-856.
doi: 10.1590/S1677-5538.IBJU.2016.0598.

Partial nephrectomy for T3aN0M0 renal cell carcinoma: shall we step forward?

Ding Peng  1 , Zhi-Song He  1 , Xue-Song Li  1 , Qi Tang  1 , Lei Zhang  1 , Kai-Wei Yang  1 , Xiao-Teng Yu  1 , Cui-Jian Zhang  1 , Li-Qun Zhou  1
Affiliations
Comparative Study

Partial nephrectomy for T3aN0M0 renal cell carcinoma: shall we step forward?

Ding Peng et al. Int Braz J Urol. 2017 Sep-Oct.

Abstract

Objectives: To evaluate the prognosis of non-metastatic T3a renal cell carcinoma (RCC) with partial nephrectomy (PN).

Patients and methods: We retrospectively evaluated 125 patients with non-metastatic T3a RCC. Patients undergoing PN and radical nephrectomy (RN) were strictly matched by clinic-pathologic characteristics. Log-rank test and Cox regression model were used for univariate and multivariate analysis.

Results: 18 pair patients were matched and the median follow-up was 35.5 (10-86) months. PN patients had a higher postoperative eGFR than RN patients (P=0.034). Cancer-specific survival (CSS) and recurrence-free survival (RFS) did not differ between two groups (P=0.305 and P=0.524). On multivariate analysis, CSS decreased with positive surgical margin and anemia (both P<0.01) and RFS decreased with Furhman grade, positive surgical margin, and anemia (all P<0.01).

Conclusions: For patients with non-metastatic pT3a RCC, PN may be a possible option for similar oncology outcomes and better renal function.

Keywords: Carcinoma, Renal Cell; Nephrectomy; Patients.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1. Kaplan-Meier survival analysis of patients with non-metastatic pT3a renal cell carcinoma (RCC) who underwent radical nephrectomy (RN) and partial nephrectomy (PN). A) Cancer-specific survival (P=0.305); B) Recurrence-free survival (P=0.524).
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