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Case Reports
. 2017 Sep 1;56(17):2307-2310.
doi: 10.2169/internalmedicine.8742-16. Epub 2017 Aug 10.

Edoxaban was Effective for Treating Renal Vein Thrombosis in a Patient with Nephrotic Syndrome

Yoshitaka Shimada  1 , Yasushi Nagaba  1 , Hide Nagaba  1 , Mariko Kamata  2 , Junya Murano  2 , Fumi Kamata  2 , Chikako Okina  2 , Hiroshi Nonoguchi  1 , Hajime Shimada  1 , Yasuo Takeuchi  2
Affiliations
Case Reports

Edoxaban was Effective for Treating Renal Vein Thrombosis in a Patient with Nephrotic Syndrome

Yoshitaka Shimada et al. Intern Med. .

Abstract

A 39-year-old man with nephrotic syndrome was admitted due to right dorsal pain. Contrast-enhanced CT led to a diagnosis of renal vein thrombosis and segmental pulmonary thromboembolism. Treatment with heparin and warfarin was started. After 1 month, pulmonary thromboembolism recurred. Warfarin was switched to edoxaban, and steroid therapy was initiated, which led to the remission of nephrotic syndrome and the disappearance of renal vein thrombosis. The efficacy of edoxaban was demonstrated; however, this drug has not been routinely selected for patients with renal disease. Our results suggest that edoxaban is also effective for treating venous thrombosis patients with nephrotic syndrome.

Keywords: edoxaban; nephrotic syndrome; renal vein thrombosis.

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Figures

Figure 1.
Figure 1.
The clinical course. PSL: prednisolone, WF: warfarin, Cr: creatinine
Figure 2.
Figure 2.
Abdominal CT on admission showing renal vein thrombosis (arrows).
Figure 3.
Figure 3.
Abdominal CT on admission showing renal vein thrombosis (arrow).
See this image and copyright information in PMC

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