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Review
. 2017 Jul 28:6:1261.
doi: 10.12688/f1000research.10506.1. eCollection 2017.

Recent advances in understanding Pseudomonas aeruginosa as a pathogen

Jens Klockgether  1 , Burkhard Tümmler  1   2
Affiliations
Review

Recent advances in understanding Pseudomonas aeruginosa as a pathogen

Jens Klockgether et al. F1000Res. .

Abstract

The versatile and ubiquitous Pseudomonas aeruginosa is an opportunistic pathogen causing acute and chronic infections in predisposed human subjects. Here we review recent progress in understanding P. aeruginosa population biology and virulence, its cyclic di-GMP-mediated switches of lifestyle, and its interaction with the mammalian host as well as the role of the type III and type VI secretion systems in P. aeruginosa infection.

Keywords: Pseudomonas aeruginosa; T3SS; T6SS; c-di-GMP; type III secretion system; type VI secretion system.

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Conflict of interest statement

Competing interests: The authors declare that they have no competing interests.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

Figures

Figure 1.
Figure 1.. Phylogenetic tree of Pseudomonas aeruginosa strains representing the 20 most common clones in the global P. aeruginosa population , .
Clones are designated by a hexadecimal code representing single nucleotide polymorphisms (SNPs) at seven conserved loci of the core genome and the subtypes of exoU/ exoS and fliC . The B420 clone represents the PA7-outlier group, D421, EC21, F469, E429, and F429 the ExoU-positive clade, and all other clones the ExoS-positive clade. The tree is based on paired genome-wide comparisons of SNPs in the core genome . The scale indicates the sequence diversity. Reproduced from Figure 5 of .
See this image and copyright information in PMC

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