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. 2017 Sep 1;82(17):9006-9011.
doi: 10.1021/acs.joc.7b01410. Epub 2017 Aug 16.

Praseodymium(III)-Catalyzed Regioselective Synthesis of C3-N-Substituted Coumarins with Coumarins and Azides

Jiu-Ling Li  1 , Da-Chao Hu  1 , Xin-Ping Liang  1 , Ying-Chun Wang  2 , Heng-Shan Wang  1 , Ying-Ming Pan  1
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Praseodymium(III)-Catalyzed Regioselective Synthesis of C3-N-Substituted Coumarins with Coumarins and Azides

Jiu-Ling Li et al. J Org Chem. .

Abstract

A series of C3-N-substituted coumarins were synthesized in good yields directly from coumarins and azides in the presence of Pr(OTf)3 without any additives or ligands needed. The selected compounds 3a, 3c-e, 3g, 3i, 3q, 3u, and 3v exhibited good anticancer activities against MGC-803, A549, and NCI-H460 cell lines with IC50 in the range 8.75-38.54 μmol L-1.

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