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Review
. 2017 Nov;20(6):447-452.
doi: 10.1097/MCO.0000000000000409.

Altered satellite cell dynamics accompany skeletal muscle atrophy during chronic illness, disuse, and aging

Colleen F McKenna  1 , Christopher S Fry
Affiliations
Review

Altered satellite cell dynamics accompany skeletal muscle atrophy during chronic illness, disuse, and aging

Colleen F McKenna et al. Curr Opin Clin Nutr Metab Care. 2017 Nov.

Abstract

Purpose of review: This review explores recent research investigating the contribution of satellite cells (skeletal muscle stem cells) during muscle fiber atrophy as seen in periods of disuse, illness, and aging.

Recent findings: Studies indicate reduced satellite cell activity and density in a variety of acute and chronic conditions characterized by robust muscle wasting. The direct contribution of satellite cells to unloading/denervation and chronic illness-induced atrophy remains controversial. Inflammation that accompanies acute trauma and illness likely impedes proper satellite cell differentiation and myogenesis, promoting the rapid onset of muscle wasting in these conditions. Transgenic mouse studies provide surprising evidence that age-related declines in satellite cell function and abundance are not causally related to the onset of sarcopenia in sedentary animals.

Summary: Recent clinical and preclinical studies indicate reduced abundance and dysregulated satellite cell activity that accompany muscle atrophy during periods of disuse, illness, and aging, providing evidence for their therapeutic potential.

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Conflict of interest statement

Conflicts of interest

The authors have no conflicts of interest

Figures

Figure 1
Figure 1. Perturbations in satellite cell activity accompany acute and chronic muscle wasting
Various pathologies that promote muscle atrophy also affect satellite cell function. Enhancement of intrinsic factors (miR-206, AT2R) within satellite cells may address impaired differentiation and improve skeletal muscles’ regenerative response. Additionally, targeting satellite cell proliferative capacity through exogenous inputs (isosorbide dinitrate) may restore reduced abundance.
See this image and copyright information in PMC

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