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. 1986 Nov 12;397(2):372-6.
doi: 10.1016/0006-8993(86)90641-4.

Functional recovery in a rat model of Parkinson's disease following transplantation of cultured human sympathetic neurons

H Kamo, S U Kim, P L McGeer, D H Shin

Functional recovery in a rat model of Parkinson's disease following transplantation of cultured human sympathetic neurons

H Kamo et al. Brain Res. .

Abstract

Rats subjected to a unilateral 6-hydroxydopamine (6-OHDA)-induced lesion of the nigrostriatal dopamine pathway were given transplants of cultured fetal human sympathetic neurons. Amphetamine-induced turning behavior in these rats was reversed by the transplants after 1.5-4.5 months. The presence of transplanted neurons and their processes was demonstrated by immunohistochemistry for tyrosine hydroxylase.

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