doi: 10.1016/0006-8993(86)90610-4.
Stimulation of hypothalamic beta-endorphin and dynorphin release by corticotropin-releasing factor (in vitro)
- PMID: 2879612
- DOI: 10.1016/0006-8993(86)90610-4
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Stimulation of hypothalamic beta-endorphin and dynorphin release by corticotropin-releasing factor (in vitro)
Brain Res.
.
Abstract
Corticotropin-releasing factor (CRF) at doses of 10(-12)-10(-8) M significantly stimulated the release of beta-endorphin and dynorphin from superfused rat hypothalamic slices. These effects were shown to be mediated by the CRF receptor since they were antagonized by the CRF receptor antagonist alpha-helical CRF9-41 (10(-6) M). The two opioid peptides showed different time courses of response and in the case of beta-endorphin, an attenuation of the response upon continued exposure to CRF was observed.
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