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Case Reports
. 2017 Aug 3;22(31):30584.
doi: 10.2807/1560-7917.ES.2017.22.31.30584.

Novel mcr-3 variant, encoding mobile colistin resistance, in an ST131 Escherichia coli isolate from bloodstream infection, Denmark, 2014

Louise Roer  1 , Frank Hansen  1 , Marc Stegger  1 , Ute Wolff Sönksen  1 , Henrik Hasman  1 , Anette M Hammerum  1
Affiliations
Case Reports

Novel mcr-3 variant, encoding mobile colistin resistance, in an ST131 Escherichia coli isolate from bloodstream infection, Denmark, 2014

Louise Roer et al. Euro Surveill. .

Abstract

A novel variant of the plasmid-borne colistin resistance gene mcr-3 was detected on an IncHI2 plasmid in an ST131 CTX-M-55-producing Escherichia coli isolate from a Danish patient with bloodstream infection in 2014. The discovery of novel plasmid-borne genes conferring resistance to colistin is of special interest since colistin has reemerged as an important drug in the treatment of infections with multidrug-resistant Gram-negative bacteria.

Keywords: Escherichia coli; antimicrobial resistance; bacterial infections.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure
Figure
Sequence comparison of mcr-3 plasmid pWJ1 with mcr-3-variant of Escherichia coli patient isolate SNTR36B6, Denmark, September 2014
See this image and copyright information in PMC

References

    1. Yin W, Li H, Shen Y, Liu Z, Wang S, Shen Z, et al. Novel Plasmid-Mediated Colistin Resistance Gene mcr-3 in Escherichia coli. MBio. 2017;8(3):e00543-17. 10.1128/mBio.00543-17 - DOI - PMC - PubMed
    1. European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint tables for interpretation of MICs and zone diameters. Version 6.0. Växjö: EUCAST; 1 Jan 2016. Available from: http://www.eucast.org/fileadmin/src/media/PDFs/EUCAST_files/Breakpoint_t...
    1. Hasman H, Hammerum AM, Hansen F, Hendriksen RS, Olesen B, Agersø Y, et al. Detection of mcr-1 encoding plasmid-mediated colistin-resistant Escherichia coli isolates from human bloodstream infection and imported chicken meat, Denmark 2015. Euro Surveill. 2015;20(49):30085. 10.2807/1560-7917.ES.2015.20.49.30085 - DOI - PubMed
    1. Zankari E, Hasman H, Cosentino S, Vestergaard M, Rasmussen S, Lund O, et al. Identification of acquired antimicrobial resistance genes. J Antimicrob Chemother. 2012;67(11):2640-4. 10.1093/jac/dks261 - DOI - PMC - PubMed
    1. Roer L, Hansen F, Thomsen MCF, Knudsen JD, Hansen DS, Wang M, et al. WGS-based surveillance of third-generation cephalosporin-resistant Escherichia coli from bloodstream infections in Denmark. J Antimicrob Chemother. 2017;72(7):1922-9. 10.1093/jac/dkx092 - DOI - PubMed

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