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. 2017:2017:1403940.
doi: 10.1155/2017/1403940. Epub 2017 Jul 17.

Altered Brain Functional Connectivity in Small-Cell Lung Cancer Patients after Chemotherapy Treatment: A Resting-State fMRI Study

Konstantinos Bromis  1 , Kostakis Gkiatis  1 , Irene Karanasiou  2 , George Matsopoulos  1 , Eustratios Karavasilis  3 , Matilda Papathanasiou  4 , Efstathios Efstathopoulos  4 , Nikolaos Kelekis  4 , Vasileios Kouloulias  4
Affiliations

Altered Brain Functional Connectivity in Small-Cell Lung Cancer Patients after Chemotherapy Treatment: A Resting-State fMRI Study

Konstantinos Bromis et al. Comput Math Methods Med. 2017.

Abstract

Previous studies in small-cell lung cancer (SCLC) patients have mainly focused on exploring neurocognitive deficits associated with prophylactic cranial irradiation (PCI). Little is known about functional brain alterations that might occur due to chemotherapy treatment in this population before PCI is administered. For this reason, we used resting-state functional Magnetic Resonance Imaging (fMRI) to examine potential functional connectivity disruptions in brain networks, including the Default Mode Network (DMN), the Sensorimotor Network, and the Task-Positive Network (TPN). Nineteen SCLC patients after platinum-based chemotherapy treatment and thirteen controls were recruited in the current study. ROI-to-ROI and Seed-to-Voxel analyses were carried out and revealed functional connectivity deficits in patients within all the networks investigated demonstrating the possible negative effect of chemotherapy in cognitive functions in SCLC populations.

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Figures

Figure 1
Figure 1
Functional connectivity map of the ROI-to-ROI analysis for the DMN (p-FDR < 0.05). Line thickness corresponds to the actual p value of the connection. The color of the balls denoting the ROIs signifies the p value of the connection according to the colorbar.
Figure 2
Figure 2
Functional connectivity map of the Seed-to-Voxel analysis for the DMN (p-unc < 0.0001; cluster p-FDR < 0.05). Red color indicates positive correlation while blue color indicates negative correlation.
Figure 3
Figure 3
Functional connectivity map of the ROI-to-ROI analysis for the TPN (p-FDR < 0.05). Line thickness corresponds to the actual p value of the connection. The color of the balls denoting the ROIs signifies the p value of the connection according to the colorbar.
Figure 4
Figure 4
Functional connectivity map of the Seed-to-Voxel analysis for the TPN (p-unc < 0.0001; cluster p-FDR < 0.05). Red color indicates positive correlation while blue color indicates negative correlation.
Figure 5
Figure 5
Functional connectivity map of the ROI-to-ROI analysis for the SMN (p-FDR < 0.05). Line thickness corresponds to the actual p value of the connection. The color of the balls denoting the ROIs signifies the p value of the connection according to the colorbar.
Figure 6
Figure 6
Functional connectivity map of the Seed-to-Voxel analysis for the SMN (p-unc < 0.0001; cluster p-FDR < 0.05). Red color indicates positive correlation while blue color indicates negative correlation.
Figure 7
Figure 7
ROI-to-ROI analysis. Statistically significant lower functional connectivity in the patients compared to controls for the DMN (p-FDR < 0.05). Line thickness corresponds to the actual p value of the difference between the two groups. The color of the balls denoting the ROIs signifies the p value of the difference between the two groups according to the colorbar.
Figure 8
Figure 8
Seed-to-Voxel analysis. Statistically significant lower functional connectivity in the patients compared to controls for the DMN (voxel p-unc < 0.01; cluster p-FDR < 0.05). Red color indicates cluster with decreased functional connectivity for the patients.
Figure 9
Figure 9
ROI-to-ROI analysis. Statistically significant lower functional connectivity in the patients compared to controls for the TPN (p-FDR < 0.05). Line thickness corresponds to the actual p value of the difference between the two groups. The color of the balls denoting the ROIs signifies the p value of the difference between the two groups according to the colorbar.
Figure 10
Figure 10
Seed-to-Voxel analysis. Statistically significant lower functional connectivity in the patients compared to controls for the TPN (voxel p-unc < 0.01; cluster p-FDR < 0.05). Red color indicates cluster with decreased functional connectivity for the patients.
Figure 11
Figure 11
ROI-to-ROI analysis. Statistically significant lower functional connectivity in the patients compared to controls for the SMN (p-FDR < 0.05). Line thickness corresponds to the actual p value of the difference between the two groups. The color of the balls denoting the ROIs signifies the p value of the difference between the two groups according to the colorbar.
Figure 12
Figure 12
Seed-to-Voxel analysis. Statistically significant lower functional connectivity in the patients compared to controls for the SMN (voxel p-unc < 0.01; cluster p-FDR < 0.05). Red color indicates cluster with decreased functional connectivity for the patients.
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References

    1. Zhu H., Zhou Z., Wang Y., et al. Thoracic radiation therapy improves the overall survival of patients with extensive-stage small cell lung cancer with distant metastasis. Cancer. 2011;117(23):5423–5431. doi: 10.1002/cncr.26206. - DOI - PubMed
    1. Zhang W., Jiang W., Luan L., Wang L., Zheng X., Wang G. Prophylactic cranial irradiation for patients with small-cell lung cancer: A systematic review of the literature with meta-analysis. BMC Cancer. 2014;14(1, article no. 793) doi: 10.1186/1471-2407-14-793. - DOI - PMC - PubMed
    1. Aupérin A., Arriagada R., Pignon J.-P., et al. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. New England Journal of Medicine. 1999;341(7):476–484. doi: 10.1056/NEJM199908123410703. - DOI - PubMed
    1. Chen Y., Li J., Hu Y., et al. Prophylactic cranial irradiation could improve overall survival in patients with extensive small cell lung cancer: A retrospective study. Strahlentherapie und Onkologie. 2016;192(12):905–912. doi: 10.1007/s00066-016-1038-0. - DOI - PubMed
    1. Welzel G., Fleckenstein K., Schaefer J., et al. Memory Function Before and After Whole Brain Radiotherapy in Patients With and Without Brain Metastases. International Journal of Radiation Oncology Biology Physics. 2008;72(5):1311–1318. doi: 10.1016/j.ijrobp.2008.03.009. - DOI - PubMed

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