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. 1986 Dec;23(6):491-3.
doi: 10.1136/jmg.23.6.491.

Paternal inheritance of translocation chromosomes in a t(X;21) patient with X linked muscular dystrophy

V M Kean, H L Macleod, M W Thompson, P N Ray, C Verellen-Dumoulin, R G Worton

Paternal inheritance of translocation chromosomes in a t(X;21) patient with X linked muscular dystrophy

V M Kean et al. J Med Genet. 1986 Dec.

Abstract

A number of DNA probes from the short arm of the X chromosome have been used to study the inheritance of the translocation chromosomes in a girl with an X; autosome translocation and muscular dystrophy. The two translocation chromosomes were found to be derived from the father's single normal X chromosome, ruling out maternal inheritance of a pre-existent mutation and enhancing the concept that the de novo translocation is responsible for the dystrophic phenotype.

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