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Case Reports
. 1987 Jan 17;1(8525):132-5.
doi: 10.1016/s0140-6736(87)91968-4.

Response of human-immunodeficiency-virus-associated neurological disease to 3'-azido-3'-deoxythymidine

R Yarchoan, G Berg, P Brouwers, M A Fischl, A R Spitzer, A Wichman, J Grafman, R V Thomas, B Safai, A Brunetti, et al.
Free article
Case Reports

Response of human-immunodeficiency-virus-associated neurological disease to 3'-azido-3'-deoxythymidine

R Yarchoan et al. Lancet. .
Free article

Abstract

Four patients with human-immuno-deficiency-virus-associated neurological disease were treated with 3'-azido-3'-deoxythymidine (AZT). Three (two with chronic dementia, and one with chronic dementia and peripheral neuropathy) improved as assessed by clinical examination, psychometric tests, nerve conduction studies, and/or positron emission tomography; there was no improvement in the fourth patient who presented with paraplegia. These results support the hypothesis that certain AIDS-virus-associated neurological abnormalities are reversible by antiretroviral chemotherapy.

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