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. 1987 Feb 14;1(8529):355-7.
doi: 10.1016/s0140-6736(87)91728-4.

Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease

A Waage, A Halstensen, T Espevik

Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease

A Waage et al. Lancet. .

Abstract

Serum samples taken on admission from 79 patients with meningococcal meningitis, septicaemia, or both, were examined in a highly sensitive bioassay for tumour necrosis factor (TNF). TNF was detected in samples from 10 of 11 patients who died but from only 8 of 68 survivors. All 5 patients with serum TNF levels over 440 units/ml (corresponding to 0.1 ng/ml recombinant TNF) died.

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