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. 2017 Sep:106:53-55.
doi: 10.1016/j.tube.2017.06.005. Epub 2017 Jul 3.

Detection of Mycobacterium tuberculosis from paraffin-embedded tissues by GeneXpert MTB/RIF

Laura Rindi  1 , Greta Alì  2 , Barbara Fabiani  3 , Gabriella Fontanini  4 , Carlo Garzelli  3
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Detection of Mycobacterium tuberculosis from paraffin-embedded tissues by GeneXpert MTB/RIF

Laura Rindi et al. Tuberculosis (Edinb). 2017 Sep.

Abstract

GeneXpert MTB/RIF (Xpert) assay, a rapid and automated system based on real-time PCR and molecular beacon technology, proved to be a sensitive and specific tool capable of detecting Mycobacterium tuberculosis and rifampin resistance in clinical specimens. In this study we provide a Xpert-dedicated successful protocol for processing paraffin-embedded tissue and assess the feasibility of the Xpert assay-based tuberculosis (TB) diagnosis on these specimens, thus proving the Xpert assay as a valuable TB diagnostic tool in supporting conventional histopathological methods.

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