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Review
. 2017 Sep;37(3):503-525.
doi: 10.1016/j.cll.2017.06.003.

Cutaneous Squamous Cell Carcinoma

Vishwas Parekh  1 , John T Seykora  2
Affiliations
Review

Cutaneous Squamous Cell Carcinoma

Vishwas Parekh et al. Clin Lab Med. 2017 Sep.

Abstract

Cutaneous squamous cell carcinoma (cSCC) is a malignant neoplasm of the skin characterized by an aberrant proliferation of keratinocytes. Cutaneous SCC is the second most common malignancy globally, and usually arises in the chronically sun-damaged skin of elderly white individuals. From a pathologist's perspective, it is important to differentiate cSCC from the benign and reactive squamoproliferative lesions and identify the high-risk features associated with aggressive tumor behavior. In this article, we provide an up-to-date overview of cSCC along with its precursor lesions and important histologic variants, with a particular emphasis on the histopathologic features and molecular pathogenesis.

Keywords: Acantholytic squamous cell carcinoma; Actinic keratosis; Desmoplastic squamous cell carcinoma; Keratoacanthoma; Pathogenesis; Spindle cell squamous cell carcinoma; Squamous cell carcinoma.

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