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. 1986 Dec 22;14(24):9927-32.
doi: 10.1093/nar/14.24.9927.

Linkage of tyrosine hydroxylase to four other markers on the short arm of chromosome 11

P A Moss, K E Davies, C Boni, J Mallet, S T Reeders
Free PMC article

Linkage of tyrosine hydroxylase to four other markers on the short arm of chromosome 11

P A Moss et al. Nucleic Acids Res. .
Free PMC article

Abstract

Tyrosine hydroxylase is the rate-limiting enzyme in catecholamine synthesis; the gene has previously been cloned and localised to the short arm of chromosome 11. Because of the interest in tyrosine hydroxylase as a candidate gene for manic-depressive psychosis and other affective disorders, we carried out family studies to determine the linkage of tyrosine hydroxylase with insulin, beta-globin, D11S12 and Harvey-ras 1, members of a linkage group which has previously been localised to 11p. Using DNA from the Centre d'Etude du Polymorphisme Humain (CEPH) and from two large British pedigrees, we show that tyrosine hydroxylase is closely linked to these four loci (z = 7.36, theta = 0.04 for linkage to insulin) and suggest a gene order based on multipoint mapping.

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