Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2017 Oct;134(4):667-669.
doi: 10.1007/s00401-017-1763-1. Epub 2017 Aug 12.

Brainstem angiocentric gliomas with MYB-QKI rearrangements

Laura D'Aronco  1 , Cécile Rouleau  2   3 , Tenzin Gayden  3 , Louis Crevier  4 , Jean-Claude Décarie  5 , Sébastien Perreault  6 , Nada Jabado  3 , Pratiti Bandopadhayay  2   3 , Keith L Ligon  7 , Benjamin Ellezam  8
Affiliations
Case Reports

Brainstem angiocentric gliomas with MYB-QKI rearrangements

Laura D'Aronco et al. Acta Neuropathol. 2017 Oct.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Case 1. Photomicrographs of representative H&E tissue section (A) showing low-cellularity glial tumor with growth along blood vessels or in a perpendicular orientation (inset), with entrapped neurons. Cytologic smear (B) and tissue section (C) highlighting longitudinal growth along blood vessels and elongated nuclei with finely speckled chromatin. D Immunohistochemistry for EMA showing surface and cytoplasmic positivity. MRI images showing a T2-hyperintense (E), FLAIR-hyperintense (F), T1-hypointense non-contrast enhancing (G), dorsally exophytic mass infiltrating pons and medulla. (H) Sanger sequencing of MYB-QKI fusion transcript. Initial magnification in A, 200x; inset, 400x; B-D, 630x
Fig. 2
Fig. 2
Case 2. Photomicrographs of representative H&E tissue sections showing low-cellularity glial tumor with angiocentric growth (A and C), entrapped neurons (B), and growth in a perpendicular orientation (D). MRI images showing a T1-hypointense (E), FLAIR-hyperintense (F), non-contrast enhancing (G), dorsally exophytic mass infiltrating pons and medulla. H Next-generation sequencing (OncoPanelTM) showing 6q deletion suggestive of MYB-QKI fusion. Initial magnification in A, 200x; B-D, 600x
See this image and copyright information in PMC

References

    1. Ampie L, Choy W, DiDomenico JD, Lamano JB, Williams CK, Kesavabhotla K, Mao Q, Bloch O (2016) Clinical attributes and surgical outcomes of angiocentric gliomas. J Clin Neurosci 28: 117–122 Doi 10.1016/j.jocn.2015.11.015 - DOI - PubMed
    1. Bandopadhayay P, Ramkissoon LA, Jain P et al. (2016) MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism. Nat Genet 48: 273–282 Doi 10.1038/ng.3500 - DOI - PMC - PubMed
    1. Covington DB, Rosenblum MK, Brathwaite CD, Sandberg DI (2009) Angiocentric glioma-like tumor of the midbrain. Pediatr Neurosurg 45: 429–433 Doi 10.1159/000277616 - DOI - PubMed
    1. Burger PC, Jouvet A, Preusser M, Rosenblum MK, Ellison DW (2016) Angiocentric Glioma In: Louis DN, Ohgaki H, Wielster OD, Cavenee WK, Ellison DW, Figarella-Branger D, Perry A, Reifenberger G, Von Deimling A (eds) WHO Classification of Tumours of the Central Nervous System, revised 4th edn Internationnal Agency for Research on Cancer, Lyon, pp 119–120
    1. Qaddoumi I, Orisme W, Wen J et al. (2016) Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology. Acta Neuropathol. 131:833–45. doi: 10.1007/s00401-016-1539-z. - DOI - PMC - PubMed

LinkOut - more resources