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. 2017;4(2):e1561.
Epub 2017 Jun 19.

Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury

Shi-Ying Cai  1 , James L Boyer  1
Affiliations

Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury

Shi-Ying Cai et al. Inflamm Cell Signal. 2017.

Abstract

The mechanism of bile acid induced cholestatic liver injury remains controversial, thus hindering the development of new therapies for these diseases. In this research highlight, we briefly review the evolution of our understanding of the pathogenesis of bile acid induced liver injury, and summarize our recent findings on this topic. Our data suggests that under pathophysiological conditions bile acid induced liver injury is mediated by inflammatory responses that are initiated from stressed hepatocytes. We conclude by mentioning potential new therapeutic approaches for treating cholestatic liver injury based on these pathophysiologic concepts.

Keywords: Bile acids; cholestasis; inflammatory cytokines.

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Conflict of interest statement

Conflicting interests The authors have declared that no conflict of interests exist.

References

    1. Scholmerich J, Becher MS, Schmidt K, Schubert R, Kremer B, Feldhaus S, et al. Influence of hydroxylation and conjugation of bile salts on their membrane-damaging properties--studies on isolated hepatocytes and lipid membrane vesicles. Hepatology. 1984;4:661–666. - PubMed
    1. Attili AF, Angelico M, Cantafora A, Alvaro D, Capocaccia L. Bile acid-induced liver toxicity: relation to the hydrophobic-hydrophilic balance of bile acids. Med Hypotheses. 1986;19:57–69. - PubMed
    1. Galle PR, Theilmann L, Raedsch R, Otto G, Stiehl A. Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes. Hepatology. 1990;12:486–491. - PubMed
    1. Woolbright BL, Jaeschke H. Novel insight into mechanisms of cholestatic liver injury. World J Gastroenterol. 2012;18:4985–4993. - PMC - PubMed
    1. Malhi H, Guicciardi ME, Gores GJ. Hepatocyte death: a clear and present danger. Physiol Rev. 2010;90:1165–1194. - PMC - PubMed

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