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Case Reports
. 2017 Nov;8(6):698-702.
doi: 10.1111/1759-7714.12485. Epub 2017 Aug 14.

Vagus nerve schwannoma in the right upper mediastinum

WeiPeng Zhu  1 , DongHong Chen  1
Affiliations
Case Reports

Vagus nerve schwannoma in the right upper mediastinum

WeiPeng Zhu et al. Thorac Cancer. 2017 Nov.

Abstract

A 35-year-old woman was admitted to our hospital with an abnormal shadow on her chest roentgenogram. Computed tomography showed that a tumor was located in the right upper mediastinum. Resection of the tumor by video-assisted thoracoscopic surgery was performed. Operative findings determined that the tumor originated from the right vagus nerve and was diagnosed as schwannoma by pathological examination.

Keywords: Mediastinum; schwannoma; vagus nerve.

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Figures

Figure 1
Figure 1
(a) Chest roentgenogram showed a right superior lung field mass protruding from the mediastinum (white arrow). (b) Computed tomography (CT) scan showed a clear boundary mass in the right superior mediastinum but no evidence of invasion into adjacent tissue. (c) The arterial phase of the contrast enhanced CT scan showed slightly heterogeneous enhancement of the tumor. (d) The venous phase showed a similar result.
Figure 2
Figure 2
(a) Appearance of the tumor under thoracoscopy. ant, patient's front; apex, patient's apex; RUL, right upper lobe; SVC, superior vena cava. (b) The tumor is near and distal to the branching point of the recurrent laryngeal nerve. RLN, recurrent laryngeal nerve; RSA, right subclavian artery; RSV, right subclavian vein; VNT, vagus nerve trunk. (c) Tumor resection through vagus nerve amputation. VN stump, vagus nerve stump. (d) Distal side of the tumor. distal VN, distal side of the vagus nerve.
Figure 3
Figure 3
(a) Cut surface of the specimen. (b) Antoni A zone (hematoxylin and eosin; magnification ×200). (c) Antoni B zone (hematoxylin and eosin; magnification ×200). (d) Immunohistochemistry for S 100 protein exhibited strong positivity (magnification ×200).
See this image and copyright information in PMC

References

    1. Das Gupta TK, Brasfield RD, Strong EW, Hajdu SI. Benign solitary schwannomas (neurilemomas). Cancer 1969; 24: 355–66. - PubMed
    1. Takeda S, Miyoshi S, Minami M, Matsuda H. Intrathoracic neurogenic tumors‐‐50 years' experience in a Japanese institution. Eur J Cardiothorac Surg 2004; 26: 807–12. - PubMed
    1. Singer RL. Thoracoscopic excision of a malignant schwannoma of the intrathoracic vagus nerve. Ann Thorac Surg 1995; 59: 1586–7. - PubMed
    1. Park BJ, Carrasquillo J, Bains MS, Flores RM. Giant benign esophageal schwannoma requiring esophagectomy. Ann Thorac Surg 2006; 82: 340–2. - PubMed
    1. Eguchi T, Yoshida K, Kobayashi N et al Multiple schwannomas of the bilateral mediastinal vagus nerves. Ann Thorac Surg 2011; 91: 1280–1. - PubMed

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