doi: 10.1016/s0006-291x(86)80136-x.
The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein
- PMID: 2880583
- DOI: 10.1016/s0006-291x(86)80136-x
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The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein
Biochem Biophys Res Commun.
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Abstract
The development of simultaneous resistance to multiple drugs in cultured cells occurs after selection for resistance to single agents. This multidrug-resistance phenotype is thought to mimic multidrug-resistance in human tumors treated with chemotherapy. Both the expression of a membrane protein, termed P170 or P-glycoprotein, and the expression of a cloned DNA fragment, termed mdr1, have been shown independently to be associated with multidrug-resistance in cultured cells. In this work, we show that human KB carcinoma cells which express the mdr1 gene also express P-glycoprotein, and that cDNAs encoding P-glycoprotein cross-hybridize with mdr1 cDNAs. Thus, the mdr1 gene codes for P-glycoprotein.
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