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Multicenter Study
. 2017 Nov;40(11):955-961.
doi: 10.1002/clc.22774. Epub 2017 Aug 14.

Study of young patients with myocardial infarction: Design and rationale of the YOUNG-MI Registry

Avinainder Singh  1 , Bradley Collins  1 , Arman Qamar  2 , Ankur Gupta  1 , Amber Fatima  1 , Sanjay Divakaran  2 , Josh Klein  1 , Jon Hainer  1 , Petr Jarolim  3 , Ravi V Shah  4 , Khurram Nasir  5 , Marcelo F Di Carli  1 , Deepak L Bhatt  2 , Ron Blankstein  1
Affiliations
Multicenter Study

Study of young patients with myocardial infarction: Design and rationale of the YOUNG-MI Registry

Avinainder Singh et al. Clin Cardiol. 2017 Nov.

Abstract

The YOUNG-MI registry is a retrospective study examining a cohort of young adults age ≤ 50 years with a first-time myocardial infarction. The study will use the robust electronic health records of 2 large academic medical centers, as well as detailed chart review of all patients, to generate high-quality longitudinal data regarding the clinical characteristics, management, and outcomes of patients who experience a myocardial infarction at a young age. Our findings will provide important insights regarding prevention, risk stratification, treatment, and outcomes of cardiovascular disease in this understudied population, as well as identify disparities which, if addressed, can lead to further improvement in patient outcomes.

Keywords: Atherosclerosis; Gender; Ischemic Heart Disease; Myocardial Infarction; Preventive Cardiology; Young Adults.

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Conflict of interest statement

Deepak L. Bhatt has served on advisory boards for Cardax, Elsevier PracticeUpdate Cardiology, Medscape Cardiology, and Regado Biosciences; has served on the board of directors for Boston VA Research Institute and Society of Cardiovascular Patient Care; has been chair of the American Heart Association Quality Oversight Committee; has served on data monitoring committees for Cleveland Clinic, Duke Clinical Research Institute, Harvard Clinical Research Institute, Mayo Clinic, Mount Sinai School of Medicine, and Population Health Research Institute; has received honoraria from American College of Cardiology (Senior Associate Editor, Clinical Trials and News, ACC.org), Belvoir Publications (editor in chief, Harvard Heart Letter), Duke Clinical Research Institute (clinical trial steering committees), Harvard Clinical Research Institute (clinical trial steering committee), HMP Communications (editor in chief, Journal of Invasive Cardiology), Journal of the American College of Cardiology (guest editor, associate editor), Population Health Research Institute (clinical trial steering committee), Slack Publications (chief medical editor, Cardiology Today's Intervention), Society of Cardiovascular Patient Care (secretary/treasurer), and WebMD (CME steering committees); has served as deputy editor for Clinical Cardiology, chair of the NCDR‐ACTION Registry Steering Committee, and chair of VA CART Research and Publications Committee; has received research funding from Amarin, Amgen, AstraZeneca, Bristol‐Myers Squibb, Chiesi, Eisai, Ethicon, Forest Laboratories, Ironwood, Ischemix, Lilly, Medtronic, Pfizer, Roche, Sanofi‐Aventis, and The Medicines Company; has received royalties from Elsevier (editor, Cardiovascular Intervention: A Companion to Braunwald's Heart Disease); has served as site co‐investigator for Biotronik, Boston Scientific, and St. Jude Medical (now Abbott); has served as trustee for the American College of Cardiology; and reports unfunded research from FlowCo, Merck, PLx Pharma, and Takeda. Ron Blankstein has served on the advisory board for Amgen, Inc., and has received research support from Amgen, Inc., and Gilead Sciences, Inc. Petr Jarolim has received research support through his institution from Abbott Laboratories, AstraZeneca, LP, Daiichi‐Sankyo, Inc., GlaxoSmithKline, Janssen Scientific Affairs, LLC, Merck & Co., Inc., Roche Diagnostics Corporation, Takeda Global Research and Development Center, and Waters Technologies Corporation. Ankur Gupta is supported by National Institutes of Health grant no. 5T32HL094301‐07. The authors declare no other potential conflicts of interest.

Figures

Figure 1
Figure 1
Schema of registry design. Abbreviations: CAD, coronary artery disease; CK‐MB, creatine kinase MB fraction; CV, cardiovascular; ICD, International Classification of Diseases; MI, myocardial infarction
Figure 2
Figure 2
Inclusion criteria, exclusion criteria, and case definition. Abbreviations: CAD, coronary artery disease; CNS, central nervous system; ECG, electrocardiogram; MI, myocardial infarction; PE, pulmonary embolism
See this image and copyright information in PMC

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