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. 2017 Aug 15;17(1):112.
doi: 10.1186/s12890-017-0452-0.

Association between Charlson comorbidity index score and outcome in patients with stage IIIB-IV non-small cell lung cancer

Lei Zhao  1 , Lai-Han Leung  2 , Jing Wang  1 , Huihui Li  1 , Juanjuan Che  1 , Lian Liu  1 , Xiaojun Yao  3 , Bangwei Cao  4
Affiliations

Association between Charlson comorbidity index score and outcome in patients with stage IIIB-IV non-small cell lung cancer

Lei Zhao et al. BMC Pulm Med. .

Abstract

Background: This retrospective study investigated the association between the Charlson comorbidity index (CCI) score and the survival of patients with stage IIIB-IV (advanced, non-resectable) non-small cell lung cancer (NSCLC) who also did not have gene mutations in epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK).

Methods: The records of 165 patients (28-80 y, median 61 y) who met the above criteria and were admitted to Beijing Friendship Hospital Capital Medical University from 1 May 2010 to 1 October 2014were reviewed. Associations between baseline variables and the CCI score were assessed via univariate and multivariate logistic regression analysis. Overall survival was defined as the time from the first clinic visit to death from any cause, or to the end of follow-up. Survival curves were estimated via the Kaplan-Meier method and compared with the log-rank test.

Results: Logistic regression analyses indicated that smoking and performance status were independently associated with the CCI score. Smoking was associated with an increased risk of mortality (odds ratio (OR) 4.12 (95% confidence interval [CI] 1.92-8.84) compared to non-smokers), as was performance status 2 (ambulatory, capable of self-care, unable to perform any work activities; active for >50% of waking hours) (OR 2.22 (95% CI, 1.14-4.33) compared to performance status 1). Univariate Cox's regression analyses showed that the hazard ratios were significantly associated with the CCI score (P = 0.009), smoking (P = 0.042), and male gender (P = 0.021).

Conclusion: The CCI score is an important prognostic factor for the prediction of overall survival in patients with stage IIIB-IV NSCLC who are negative for EGFR and ALK gene mutations.

Keywords: Advanced NSCLC; Charlson comorbidity; Index score; Outcome.

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Conflict of interest statement

Ethics approval and consent to participate

All experimental protocols for this study were approved by the Research Ethics Board of Beijing Friendship Hospital. The study complied with the Principles of the Declaration of Helsinki and received ethics approval by the respective institutional review boards. All participants provided written informed consent.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
ROC curve for best cut-off of unresectable stage IIIB-IV NSCLC patients without EGFR or ALK genetic mutations. AUC, area under curve
Fig. 2
Fig. 2
Kaplan-Meier curves for unresectable stage IIIB-IV NSCLC patients without EGFR or ALK genetic mutations, according to CCI score
See this image and copyright information in PMC

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