Role of lipid mediators in the regulation of oxidative stress and inflammatory responses in dairy cattle
- PMID: 28807478
- DOI: 10.1016/j.rvsc.2017.08.002
Role of lipid mediators in the regulation of oxidative stress and inflammatory responses in dairy cattle
Abstract
Periparturient dairy cows experience an increased incidence and severity of several inflammatory-based diseases such as mastitis and metritis. Factors associated with the physiological adaptation to the onset of lactation can impact the efficiency of the inflammatory response at a time when it is most needed to eliminate infectious pathogens that cause these economically important diseases. Oxidative stress, for example, occurs when there is an imbalance between the production of oxygen radicals during periods of high metabolic demand and the reduced capabilities of the host's antioxidant defenses. The progressive development of oxidative stress in early lactation cows is thought to be a significant underlying factor leading to dysfunctional inflammatory responses. Reactive oxygen species (ROS) are also produced by leukocytes during inflammation resulting in positive feedback loops that can further escalate oxidative stress during the periparturient period. During oxidative stress, ROS can modify polyunsaturated fatty acids (PUFA) associated with cellular membranes, resulting in the biosynthesis of oxidized products called oxylipids. Depending on the PUFA substrate and oxidation pathway, oxylipids have the capacity of either enhancing or resolving inflammation. In mediating their effects, oxylipids can directly or indirectly target sites of ROS production and thus control the degree of oxidative stress. This review discusses the evidence supporting the roles of oxylipids in the regulation of oxidative stress and the subsequent development of uncontrolled inflammatory responses. Further, the utility of some of the oxylipids as oxidative stress markers that can be exploited in developing and monitoring therapies for inflammatory-based diseases in dairy cattle is discussed. Understanding of the link between some oxylipids and the development or resolution of oxidative stress could provide novel therapeutic targets to limit immunopathology, reduce antibiotic usage, and optimize the resolution of inflammatory-based diseases in periparturient dairy cows.
Keywords: Cyclooxygenase; Cytochrome P450; Isoprostane; Lipoxygenase; Oxylipid; Oxylipin.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Similar articles
-
Symposium review: Oxylipids and the regulation of bovine mammary inflammatory responses.J Dairy Sci. 2018 Jun;101(6):5629-5641. doi: 10.3168/jds.2017-13855. Epub 2018 Feb 4. J Dairy Sci. 2018. PMID: 29397182 Review.
-
Association between polyunsaturated fatty acid-derived oxylipid biosynthesis and leukocyte inflammatory marker expression in periparturient dairy cows.J Dairy Sci. 2014;97(6):3615-25. doi: 10.3168/jds.2013-7656. Epub 2014 Apr 14. J Dairy Sci. 2014. PMID: 24731638
-
Invited review: Cytochrome P450 enzyme involvement in health and inflammatory-based diseases of dairy cattle.J Dairy Sci. 2021 Feb;104(2):1276-1290. doi: 10.3168/jds.2020-18997. Epub 2020 Dec 23. J Dairy Sci. 2021. PMID: 33358163 Review.
-
Metabolic factors affecting the inflammatory response of periparturient dairy cows.Anim Health Res Rev. 2009 Jun;10(1):53-63. doi: 10.1017/S1466252309990016. Anim Health Res Rev. 2009. PMID: 19558749 Review.
-
Polyunsaturated fatty acids influence differential biosynthesis of oxylipids and other lipid mediators during bovine coliform mastitis.J Dairy Sci. 2015 Sep;98(9):6202-15. doi: 10.3168/jds.2015-9570. Epub 2015 Jul 8. J Dairy Sci. 2015. PMID: 26162796
Cited by
-
Hepatic metabolism of grazing cows of two Holstein strains under two feeding strategies with different levels of pasture inclusion.PLoS One. 2023 Oct 26;18(10):e0290551. doi: 10.1371/journal.pone.0290551. eCollection 2023. PLoS One. 2023. PMID: 37883506 Free PMC article.
-
Activity of sEH and Oxidant Status during Systemic Bovine Coliform Mastitis.Antioxidants (Basel). 2021 May 20;10(5):812. doi: 10.3390/antiox10050812. Antioxidants (Basel). 2021. PMID: 34065244 Free PMC article.
-
Performance and Metabolic, Inflammatory, and Oxidative Stress-Related Parameters in Early Lactating Dairy Cows with High and Low Hepatic FGF21 Expression.Animals (Basel). 2022 Dec 29;13(1):131. doi: 10.3390/ani13010131. Animals (Basel). 2022. PMID: 36611740 Free PMC article.
-
Overview of the effect of rumen-protected limiting amino acids (methionine and lysine) and choline on the immunity, antioxidative, and inflammatory status of periparturient ruminants.Front Immunol. 2023 Jan 12;13:1042895. doi: 10.3389/fimmu.2022.1042895. eCollection 2022. Front Immunol. 2023. PMID: 36713436 Free PMC article. Review.
-
Cis-9, Trans-11 CLA Alleviates Lipopolysaccharide-Induced Depression of Fatty Acid Synthesis by Inhibiting Oxidative Stress and Autophagy in Bovine Mammary Epithelial Cells.Antioxidants (Basel). 2021 Dec 27;11(1):55. doi: 10.3390/antiox11010055. Antioxidants (Basel). 2021. PMID: 35052560 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources