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. 2017 Jan 19;31(3):213-225.
doi: 10.7555/JBR.31.20160087.

Association of three single nucleotide polymorphisms of ESR1with breast cancer susceptibility: a meta-analysis

Xu Hu  1 , Linfei Jiang  1 , Chenhui Tang  1 , Yuehong Ju  1 , Li Jiu  2 , Yongyue Wei  3 , Li Guo  4 , Yang Zhao  3
Affiliations

Association of three single nucleotide polymorphisms of ESR1with breast cancer susceptibility: a meta-analysis

Xu Hu et al. J Biomed Res. .

Abstract

Expression of estrogen receptors is correlated with breast cancer risk, but inconsistent results have been reported. To clarify potential estrogen receptor (ESR)-related breast cancer risk, we analyzed genetic variants ofESR1 in association with breast cancer susceptibility. We performed a meta-analysis to investigate the association between rs2234693, rs1801132, and rs2046210 (single nucleotide polymorphisms ofESR1), and breast cancer risk. Our analysis included 44 case-control studies. For rs2234693, the CC genotype had a higher risk of breast cancer compared to the TT or CT genotype. For rs2046210, the AA, GA, or GA+ GG genotype had a much higher risk compared to the GG genotype. No significant association was found for the rs1801132 polymorphism with breast cancer risk. This meta-analysis demonstrates association between the rs2234693 and rs2046210 polymorphisms ofESR1 and breast cancer risk. The correlation strength between rs2234693 and breast cancer susceptibility differs in subgroup assessment by ethnicity.

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Conflict of interest statement

The authors reported no conflict of interests.

Figures

Fig.1
Fig.1
Flow diagram of data extraction
Fig.2
Fig.2
Forest plot of the association between breast cancer risk and rs2234693 polymorphism in all population.
Fig.3
Fig.3
Forest plot of the association between breast cancer risk and rs1801132 polymorphism in all population.
Fig.4
Fig.4
Forest plot of the association between breast cancer risk and rs2046210 polymorphism in all population.
Fig.5
Fig.5
Funnel plots of the association between breast cancer risk and all three polymorphisms in all populations.
See this image and copyright information in PMC

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