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. 2017 Jan 19;31(3):256-263.
doi: 10.7555/JBR.31.20160127.

Electromyography and Fos immunostaining study establish a possible functional link between trigeminal proprioception and the oculomotor system in rats

Houcheng Liang  1   2   3 , Jingdong Zhang  1 , Pifu Luo  4 , Hongna Zhu  2 , Ying Qiao  2 , Anle Su  2 , Ting Zhang  2
Affiliations

Electromyography and Fos immunostaining study establish a possible functional link between trigeminal proprioception and the oculomotor system in rats

Houcheng Liang et al. J Biomed Res. .

Abstract

The objective of this study was to explore whether there was a functional link between trigeminal proprioception and the oculomotor system mediated through jaw muscle afferents. Electromyography (EMG) was undertaken of the levator palpebrae (LP) and superior rectus (SR), and Fos expression was detected in the brainstem following consecutive down-stretching of the lower jaw at 2-4 Hz in rats. Retrograde tracing was undertaken of the interstitial nucleus of Cajal and Darkschewitsch nucleus (INC/DN) pre-oculomotor neurons. EMG-like responses were recorded from the LP/SR during down-stretching of the lower jaw at 2-4 Hz in 3 out of 11 rats. Fos expression was induced by consecutive down-stretching of the lower jaw at 2-4 Hz for 20-30 seconds. Interestingly, Fos expression was distributed mainly in the bilateral INC/DN area. We also examined Fos-like immunoreactivity in central mesencephalic and paramedian pontine reticular formation that harbors premotor neurons controlling horizontal eye movement, but no Fos-like staining was observed therein. By injection of retrograde tracers into the oculomotor nucleus combined with Fos immunostaining, double labeled pre-oculomotor neurons were visualized to distribute in the INC/DN. In conclusions, there may exist a trigeminal proprioceptive - oculomotor system neural circuit through jaw muscle afferents in rats. Judging from Fos distribution pattern, this pathway might be related to vertical and torsional eye movements.

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Conflict of interest statement

The authors reported no conflict of interests.

Figures

Fig.1
Fig.1
Schematic drawing for down-stretching the lower jaw and EMG recording from the levator palpebrae / superior rectus (LP/SR).
Fig.2
Fig.2
Distribution of Fos-like immunoreactivities in the midbrain and pons following down-stretching jaw stimulation.
Fig.3
Fig.3
Fos expression in tracer-labeled INC/DN pre-oculomotor neurons.
See this image and copyright information in PMC

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References

    1. Brodsky CM. Pediatric Neuro-Ophthalmology[M]. Second ed. New York, Dordrecht, Heidelberg, London: Springer; 2010.
    1. Pratt SG, Beyer CK, Johnson CC. The Marcus Gunn phenomenon. A review of 71 cases[J]. Ophthalmology, 1984, 91(1): 27–30.10.1016/S0161-6420(84)34331-7 - DOI - PubMed
    1. Saitkowski RM, Glaser JS. Pediatric neuro-ophthalmology: General considerations and congenital motor and sensory anomalies[M]. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 1999.
    1. Engle EC. Oculomotility disorders arising from disruptions in brainstem motor neuron development[J]. Arch Neurol, 2007, 64(5): 633–637.10.1001/archneur.64.5.633 - DOI - PubMed
    1. Hotchkiss MG, Miller NR, Clark AW, et al. Bilateral Duane's retraction syndrome[J]. A clinical-pathologic case report. Arch Ophthalmol, 1980, 98(5): 870–874.10.1001/archopht.1980.01020030864013 - DOI - PubMed

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