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Review
. 2017 Jul 6;13(7):828-834.
doi: 10.7150/ijbs.19776. eCollection 2017.

Platelet-derived Extracellular Vesicles: An Emerging Therapeutic Approach

Shi-Cong Tao  1 , Shang-Chun Guo  2 , Chang-Qing Zhang  1   2
Affiliations
Review

Platelet-derived Extracellular Vesicles: An Emerging Therapeutic Approach

Shi-Cong Tao et al. Int J Biol Sci. .

Abstract

Extracellular vesicles (EVs) are a newly-discovered way by which cells communicate with their neighbors, as well as transporting cargos which once were considered to be limited by membrane barriers, including membrane proteins, cytosolic proteins and RNA. The discovery of platelet-derived EVs (P-EVs), the most abundant EVs in human blood, has been a very tortuous process. At first, P-EVs were identified as nothing but 'platelet dust', and subsequent research did not progress smoothly because of the limited research techniques to study EVs. Following leaps and bounds of technical progress in studying EVs, more and more attractive features of P-EVs were revealed and they began to be further researched. The aim of this review is to present the latest knowledge about the role of P-EVs in tissue repair and tumor progression. The potential mechanism of P-EVs is emphasized. Then the limitations of the present study and future research directions are discussed.

Keywords: exosome; extracellular vesicle; micro-vesicle; platelet; platelet-rich plasma.; regenerative medicine.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Participants in tissue repair. (A) The directed proliferation and differentiation of stem cells after site-specific integration. (B) The major effects of cell transplantation are credited to the cells' paracrine effects. (C) The role of P-EVs as important participants in PRP-induced tissue regeneration are similar to that of EVs in cell transplantation.
Figure 2
Figure 2
Participation of P-EVs in tumor progression.
See this image and copyright information in PMC

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