Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Oct;14(5):410-420.
doi: 10.1007/s11897-017-0355-7.

Vitamin D and Heart Failure

D Marshall Brinkley  1 , Omair M Ali  1 , Sandip K Zalawadiya  1 , Thomas J Wang  2
Affiliations
Review

Vitamin D and Heart Failure

D Marshall Brinkley et al. Curr Heart Fail Rep. 2017 Oct.

Erratum in

  • Correction to: Vitamin D and Heart Failure.
    Brinkley DM, Ali OM, Zalawadiya SK, Wang TJ. Brinkley DM, et al. Curr Heart Fail Rep. 2018 Aug;15(4):280. doi: 10.1007/s11897-018-0394-8. Curr Heart Fail Rep. 2018. PMID: 29744760

Abstract

Purpose: Vitamin D is principally known for its role in calcium homeostasis, but preclinical studies implicate multiple pathways through which vitamin D may affect cardiovascular function and influence risk for heart failure. Many adults with cardiovascular disease have low vitamin D status, making it a potential therapeutic target. We review the rationale and potential role of vitamin D supplementation in the prevention and treatment of chronic heart failure.

Recent findings: Substantial observational evidence has associated low vitamin D status with the risk of heart failure, ventricular remodeling, and clinical outcomes in heart failure, including mortality. However, trials assessing the influence of vitamin D supplementation on surrogate markers and clinical outcomes in heart failure have generally been small and inconclusive. There are insufficient data to recommend routine assessment or supplementation of vitamin D for the prevention or treatment of chronic heart failure. Prospective trials powered for clinical outcomes are warranted.

Keywords: Cardiovascular disease; Heart failure; Outcomes; Vitamin D.

PubMed Disclaimer

References

    1. Circulation. 2009 May 19;119(19):2545-52 - PubMed
    1. Clin Ther. 2005 Dec;27(12):1885-93 - PubMed
    1. Circulation. 2015 Jan 20;131(3):254-62 - PubMed
    1. N Engl J Med. 2007 Jul 19;357(3):266-81 - PubMed
    1. J Immunol. 2012 Mar 1;188(5):2127-35 - PubMed

LinkOut - more resources