Vitamin D Activity and Metabolism in Bone

Abstract

Purpose of review: In addition to the actions of the endocrine hormone, 1alpha,25-dihydroxyvitamin D (1,25(OH)₂D) in stimulating intestinal calcium absorption, the regulation of bone mineral metabolism by 1,25(OH)₂D is also considered an important contributor to calcium homeostasis. However, recent evidence suggest that 1,25(OH)₂D acting either via endocrine or autocrine pathways plays varied roles in bone, which suggests that vitamin D contributes to the maintenance of bone mineral in addition to its catabolic roles. This review highlights the contrasting evidence for the direct action for vitamin D metabolism and activity in bone.

Recent findings: Numerous cells within bone express vitamin D receptor (VDR), synthesise and catabolise 1,25(OH)₂D via 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1), and 25-hydroxyvitamin D 24-hydroxylase (CYP24A1) enzymes, respectively. Recent evidence suggests that all three genes are required to regulate processes of bone resorption, mineralization and fracture repair. The actions of vitamin D in bone appear to negatively or positively regulate bone mineral depending on the physiological and pathological circumstances, suggesting that vitamin D plays pleiotropic roles in bone.

Keywords: CYP24A1; CYP27B1; Mineralisation; Osteoblasts; Vitamin D; Vitamin D receptor.