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. 2017 Sep 1;22(5):e586-e594.
doi: 10.4317/medoral.21655.

Oral manifestations of Diabetes Mellitus. A systematic review

E Mauri-Obradors  1 , A Estrugo-Devesa, E Jané-Salas, M Viñas, J López-López
Affiliations

Oral manifestations of Diabetes Mellitus. A systematic review

E Mauri-Obradors et al. Med Oral Patol Oral Cir Bucal. .

Abstract

Background: Diabetes Mellitus has become a global epidemic and presents many complications, usually proportional to the degree and duration of hyperglycemia. The aim of this systematic review was to investigate the different oral manifestations associated with Diabetes Mellitus.

Material and methods: A MEDLINE search for "Diabetes Mellitus and oral manifestations" was performed. A further search was conducted for "diabetes" and its individual oral manifestation. Inclusion criteria were as follows: human clinical studies with a minimum of 30 patients; studies published in relevant scientific journals between January 1998 and January 2016. Nineteen studies fulfilled the inclusion criteria and were analyzed, assessing the strength of scientific evidence according to recommendations made by the Centre for Evidence-Based Medicine, Oxford (OCEBM), which permits adequate assessment of prevalence studies.

Results: A total 3,712 patients (2,084 diabetics) were included in the studies reviewed. Of the 19 studies analyzed, 4 were longitudinal studies and 15 cross-sectional studies. Periodontal disease, periapical lesions, xerostomia and taste disturbance were more prevalent among diabetic patients. An association between diabetes and caries and mucosal lesions proved positive in 5 out of 10 studies.

Conclusions: Despite multiple oral manifestations associated with DM, awareness of the associations between diabetes, oral health, and general health is inadequate. It is necessary for doctors and dentists to be aware of the various oral manifestations of diabetes in order to make an early diagnosis.

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Conflict of interest statement

Conflict of interest statement:The authors deny any conflicts of interest or financial support.

Figures

Figure 1
Figure 1
Flow chart diagram.
Figure 2
Figure 2
Pathophysiological relationship between diabetes and dental disease. Kudiyirickal adaptation of Kudiyirickal & Pappachan (30).
See this image and copyright information in PMC

References

    1. Fact Sheet No.312. Diabetes. World Health Organization: 2011. [ cited 2011 ]. [Internet] Available from: http://www.who.int/mediacentre/factsh .
    1. Duncan BB, Schmidt MI, Pankow JS, Ballantyne CM, Couper D, Vigo A. Low-Grade Systemic Inflammation and the Development of Type 2 Diabetes: The Atherosclerosis Risk in Communities Study. Diabetes. 2003;52:1799–805. - PubMed
    1. Shoelson SE, Lee J, Goldfine AB. Review series Inflammation and insulin resistance. J Clin Invest. 2006;116:1793–801. - PMC - PubMed
    1. Tandon N, Ali MK, Narayan KMV. Pharmacologic prevention of microvascular and macrovascular complications in diabetes mellitus: implications of the results of recent clinical trials in type 2 diabetes. Am J Cardiovasc Drugs. 20121;12:7–22. - PubMed
    1. Albert DA, Ward A, Allweiss P, Graves DT, Knowler WC, Kunzel C. Diabetes and oral disease: Implications for health professionals. Ann N Y Acad Sci. 2012;1255:1–15. - PMC - PubMed

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