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. 1987 Jan;39(1):13-6.
doi: 10.1111/j.2042-7158.1987.tb07154.x.

Changes in glutathione and its metabolizing enzymes in human erythrocytes and lymphocytes with age

W A Al-Turk, S J Stohs, F H el-Rashidy, S Othman

Changes in glutathione and its metabolizing enzymes in human erythrocytes and lymphocytes with age

W A Al-Turk et al. J Pharm Pharmacol. 1987 Jan.

Abstract

The levels of glutathione (GSH) and the activities of glutathione S-transferases (GST) and glutathione reductase (GSR) in human erythrocytes and lymphocytes were determined in three age groups (5-12, 25-40, 65-83 years). The levels of GSH in lymphocytes increased with age, however, its levels in erythrocytes reached a maximum in the middle age group. The activity of GST in erythrocytes and lymphocytes changed as a function of age in a pattern similar to the changes found for GSH levels. GSR activity increased from young to middle age in both erythrocytes and lymphocytes, but decreased again in the old age group.

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