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Comment
. 2017 Aug 14;32(2):131-133.
doi: 10.1016/j.ccell.2017.07.011.

New Views into the Genetic Landscape of Metastatic Breast Cancer

Xiaoyu Zhao  1 , Scott Powers  2
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Free article
Comment

New Views into the Genetic Landscape of Metastatic Breast Cancer

Xiaoyu Zhao et al. Cancer Cell. .
Free article

Abstract

Whether metastasis-specific genetic alterations exist remains controversial. The study by Yates et al. in this issue of Cancer Cell provides evidence that metastases emerge late during primary breast cancer progression and that additional driver mutations are often acquired, posing both challenges and opportunities for precision treatment of metastatic breast cancer.

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  • Genomic Evolution of Breast Cancer Metastasis and Relapse.
    Yates LR, Knappskog S, Wedge D, Farmery JHR, Gonzalez S, Martincorena I, Alexandrov LB, Van Loo P, Haugland HK, Lilleng PK, Gundem G, Gerstung M, Pappaemmanuil E, Gazinska P, Bhosle SG, Jones D, Raine K, Mudie L, Latimer C, Sawyer E, Desmedt C, Sotiriou C, Stratton MR, Sieuwerts AM, Lynch AG, Martens JW, Richardson AL, Tutt A, Lønning PE, Campbell PJ. Yates LR, et al. Cancer Cell. 2017 Aug 14;32(2):169-184.e7. doi: 10.1016/j.ccell.2017.07.005. Cancer Cell. 2017. PMID: 28810143 Free PMC article.

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