A Viro-Immunotherapy Triple Play for the Treatment of Glioblastoma
- PMID: 28810141
- DOI: 10.1016/j.ccell.2017.07.012
A Viro-Immunotherapy Triple Play for the Treatment of Glioblastoma
Abstract
In this issue of Cancer Cell, Saha et al. systematically test and optimize combination therapy strategies in a challenging model of glioblastoma. Durable complete responses were seen only when an oncolytic virus expressing IL12 was coupled with anti-CTLA-4 and anti-PD-1 therapeutics.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade.Cancer Cell. 2017 Aug 14;32(2):253-267.e5. doi: 10.1016/j.ccell.2017.07.006. Cancer Cell. 2017. PMID: 28810147 Free PMC article.
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