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Comment
. 2017 Oct;7(10):1056.
doi: 10.1158/2159-8290.CD-NB2017-116. Epub 2017 Aug 15.

Resistance Genes Identified

No authors listed
Comment

Resistance Genes Identified

No authors listed. Cancer Discov. 2017 Oct.

Abstract

A CRISPR-based screen of all 19,050 genes in the genome has revealed around 100 genes that cancer cells must express in order for T cells-and, thus, immunotherapies-to effectively recognize and kill tumors.

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  • Identification of essential genes for cancer immunotherapy.
    Patel SJ, Sanjana NE, Kishton RJ, Eidizadeh A, Vodnala SK, Cam M, Gartner JJ, Jia L, Steinberg SM, Yamamoto TN, Merchant AS, Mehta GU, Chichura A, Shalem O, Tran E, Eil R, Sukumar M, Guijarro EP, Day CP, Robbins P, Feldman S, Merlino G, Zhang F, Restifo NP. Patel SJ, et al. Nature. 2017 Aug 31;548(7669):537-542. doi: 10.1038/nature23477. Epub 2017 Aug 7. Nature. 2017. PMID: 28783722 Free PMC article.

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