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Comment
. 2017 Aug 22;114(34):8914-8916.
doi: 10.1073/pnas.1712475114. Epub 2017 Aug 15.

Inflammation correlates with symptoms in chronic fatigue syndrome

Anthony L Komaroff  1
Affiliations
Comment

Inflammation correlates with symptoms in chronic fatigue syndrome

Anthony L Komaroff. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Levels of three different immune-related molecules in healthy control subjects and in patients with CFS of different levels of severity: mild, moderate (Mod), and severe (Sev). Levels for three different molecules, CXCL10 (a chemokine), IFN-γ (a cytokine), and leptin (an adipokine) are shown as preprocessed median fluorescence intensity (MFI) ±1 SE. Results were adjusted for multiple comparisons, age, sex, race, and nonspecific binding. The horizontal dashed line is the level for each molecule found in healthy control subjects (Con). For 17 of the 51 immune-related molecules reported by Montoya et al. (3), there was a statistically significant upward trend with severity. This figure is adapted from figure 3 of Montoya et al. (3).
See this image and copyright information in PMC

Comment on

References

    1. Institute of Medicine . Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness. National Academies Press; Washington, DC: 2015. - PubMed
    1. Fukuda K, et al. International Chronic Fatigue Syndrome Study Group The chronic fatigue syndrome: A comprehensive approach to its definition and study. Ann Intern Med. 1994;121:953–959. - PubMed
    1. Montoya JG, et al. Cytokine signature associated with disease severity in chronic fatigue syndrome patients. Proc Natl Acad Sci USA. 2017;114:E7150–E7158. - PMC - PubMed
    1. Komaroff AL, Cho TA. Role of infection and neurologic dysfunction in chronic fatigue syndrome. Semin Neurol. 2011;31:325–337. - PubMed
    1. Nakatomi Y, et al. Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: An 11C-(R)-PK11195 PET study. J Nucl Med. 2014;55:945–950. - PubMed

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